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| CAS No.: | 76-38-0 |
|---|---|
| Name: | 2,2-DICHLORO-1,1-DIFLUOROETHYL METHYL ETHER |
| Molecular Structure: | |
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|
|
| Formula: | C3H4 Cl2 F2 O |
| Molecular Weight: | 164.967 |
| Synonyms: | Ether,2,2-dichloro-1,1-difluoroethyl methyl (6CI,8CI);1,1-Dichloro-2,2-difluoro-2-methoxyethane;2,2-Dichloro-1,1-difluoro-1-methoxyethane;2,2-Dichloro-1,1-difluoroethyl methyl ether;Analgizer;Anecotan;DA 759;Inhalan;Methoflurane;Methoxane;Methoxyfluran;Methoxyflurane;Methyl1,1-difluoro-2,2-dichloroethyl ether;Metofane;Metoxfluran;Metoxifluran;NSC 110432;Penthrane;Pentran;Pentrane; |
| EINECS: | 200-956-0 |
| Density: | 1.4262 |
| Melting Point: | -36°C |
| Boiling Point: | 103 °C |
| Flash Point: | 63 C |
| Solubility: | negligible |
| Appearance: | colourless liquid |
| Hazard Symbols: | R10:Flammable.; |
| Risk Codes: | R10; |
| Safety: | Moderately toxic by ingestion. Mildly toxic by inhalation. Human systemic effects by inhalation: depressed renal function. An experimental teratogen. Human mutation data reported. An eye irritant. See also ETHERS. When heated to decomposition it emits very toxic fumes of Cl− and F−. |
| PSA: | 9.23000 |
| LogP: | 2.02930 |
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| Conditions | Yield |
|---|---|
| With potassium hydroxide |
| Conditions | Yield |
|---|---|
| unter Eiskuehlung; | |
| unter Eiskuehlung; |
- 76-38-0
methoxyflurane
A
- 74-87-3
methylene chloride
B
- 593-53-3
Methyl fluoride
C
- 359-31-9
dichloroacetyl fluoride
D
- 661-75-6
2,2,2-Trichloro-1,1-difluoroethyl methyl ether
| Conditions | Yield |
|---|---|
| Stage #1: methoxyflurane With potassium hydroxide Dehydrofluorination; Heating; Stage #2: With chlorine at -40℃; Chlorination; Stage #3: With antimonypentachloride at 40℃; for 0.833333h; Fluorination; Decomposition; | A n/a B n/a C n/a D 74% |
| Conditions | Yield |
|---|---|
| With antimonypentachloride at 40℃; for 1.75h; Decomposition; | 70% |
- 76-38-0
methoxyflurane
- 37021-34-4
1,2,2,2-Tetrachloro-1-fluoroethyl methyl ether
| Conditions | Yield |
|---|---|
| Stage #1: methoxyflurane With potassium hydroxide Dehydrofluorination; Heating; Stage #2: With chlorine at -40℃; Chlorination; | 42% |
| Conditions | Yield |
|---|---|
| With chlorine unter Belichtung; | |
| With chlorine Irradiation; |
- 76-38-0
methoxyflurane
- 32776-65-1
Chlormethyl-(2,2,2-trichlor-1,1-difluor-aethyl)-aether
| Conditions | Yield |
|---|---|
| With chlorine Irradiation; |
- 76-38-0
methoxyflurane
- 25600-62-8
(2.2-Dichlor-1.1-difluor-aethyl)-dichlormethyl-aether
| Conditions | Yield |
|---|---|
| With chlorine Irradiation; |
- 76-38-0
methoxyflurane
- 32776-66-2
(2,2-Dichlor-1,1,-difluor-ethyl)-trichlormethyl-ether
| Conditions | Yield |
|---|---|
| With chlorine Irradiation; |
- 76-38-0
methoxyflurane
- 32776-67-3
Dichlormethyl-(2,2,2-trichlor-1,1-difluor-aethyl)-aether
| Conditions | Yield |
|---|---|
| With chlorine Irradiation; |
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Consensus Reports
IARC Cancer Review: Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 (1987),p. 93.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.
Standards and Recommendations
NIOSH REL: (Waste Anesthetic Gases and Vapors) CL 2 ppm/1H
Specification
Methoxyflurane, its cas register number is 76-38-0. It also can be called Penthrane; Pentrane; Anecotan. Methoxyflurane is an extremely potent and highly lipid soluble anesthetic agent. Methoxyflurane (also known as penthrane) is an inhaled analgesic used for emergency pain relief. It is metabolised by the liver and excreted by the lungs, and it works by depressing the patient's central nervous system. Methoxyflurane is the relatively new full-body inhalation anesthetic. In the known inhalation anesthetic, it has the strongest performance of general anesthesia and has a clear role in muscles' relaxation. It is generally now used for light anesthesia.
Physical properties about Methoxyflurane are: (1)ACD/LogP: 1.941; (2)ACD/LogD (pH 5.5): 1.94; (3)ACD/LogD (pH 7.4): 1.94; (4)ACD/BCF (pH 5.5): 17.58; (5)ACD/BCF (pH 7.4): 17.58; (6)ACD/KOC (pH 5.5): 270.84; (7)ACD/KOC (pH 7.4): 270.84; (8)#H bond acceptors: 1; (9)#Freely Rotating Bonds: 2; (10)Index of Refraction: 1.383 ; (11)Molar Refractivity: 27.643 cm3; (12)Molar Volume: 118.508 cm3; (13)Polarizability: 10.959 10-24cm3; (14)Surface Tension: 23.0100002288818 dyne/cm; (15)Density: 1.392 g/cm3; (16)Flash Point: 10.637 °C; (17)Enthalpy of Vaporization: 32.975 kJ/mol; (18)Boiling Point: 104.999 °C at 760 mmHg; (19)Vapour Pressure: 35.0060005187988 mmHg at 25°C
You can still convert the following datas into molecular structure:
(1)InChI=1S/C3H4Cl2F2O/c1-8-3(6,7)2(4)5/h2H,1H3;
(2)InChIKey=RFKMCNOHBTXSMU-UHFFFAOYSA-N;
(3)SmilesCOC(F)(C(Cl)Cl)F
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| human | TCLo | inhalation | 3500ppm/1H (3500ppm) | KIDNEY, URETER, AND BLADDER: RENAL FUNCTION TESTS DEPRESSED | Canadian Anaesthetists' Society Journal. Vol. 21, Pg. 294, 1974. |
| mammal (species unspecified) | LC50 | inhalation | 34gm/m3 (34000mg/m3) | BEHAVIORAL: ANTIPSYCHOTIC | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(4), Pg. 55, 1980. |
| mammal (species unspecified) | LD50 | oral | 3600mg/kg (3600mg/kg) | BEHAVIORAL: ANTIPSYCHOTIC | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 24(4), Pg. 55, 1980. |
| mouse | LC50 | inhalation | 21500mg/m3 (21500mg/m3) | BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 22(7), Pg. 55, 1978. |
| mouse | LD50 | intravenous | 150mg/kg (150mg/kg) | United States Patent Document. Vol. #4168308, | |
| rat | LC50 | inhalation | 33500mg/m3/4H (33500mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 53, 1982. | |
| rat | LD50 | oral | 3600mg/kg (3600mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 53, 1982. |