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CAS No.: | 766-51-8 |
---|---|
Name: | 2-Chloroanisole |
Article Data: | 153 |
Molecular Structure: | |
Formula: | C7H7ClO |
Molecular Weight: | 142.585 |
Synonyms: | Anisole,o-chloro- (6CI,7CI,8CI);1-Chloro-2-methoxybenzene;2-Chloromethoxybenzene;2-Chlorophenol methyl ether;2-Methoxy-1-chlorobenzene;2-Methoxyphenyl chloride;NSC 155175;o-Chloroanisole;o-Chloromethoxybenzene;o-Chlorophenyl methyl ether;o-Methoxychlorobenzene; |
EINECS: | 212-167-9 |
Density: | 1.137 g/cm3 |
Melting Point: | -27oC |
Boiling Point: | 198.5 °C at 760 mmHg |
Flash Point: | 70.8 °C |
Solubility: | 0.49g/L(25 oC) |
Appearance: | clear light yellow liquid |
Safety: | 24/25 |
PSA: | 9.23000 |
LogP: | 2.34860 |
Conditions | Yield |
---|---|
With N-chloro-succinimide; copper(l) chloride In acetonitrile at 80℃; for 18h; | 97% |
With N-chloro-succinimide In acetonitrile at 80℃; for 24h; | 90% |
Conditions | Yield |
---|---|
Stage #1: 2-monochlorophenol With potassium carbonate In acetone for 0.25h; Stage #2: dimethyl sulfate In acetone for 10h; Reflux; | 96% |
With sodium hydroxide In water at 90℃; for 0.5h; | 84.6% |
With potassium hydroxide at 100℃; | |
With sodium hydroxide at 100℃; | |
With lithium hydroxide In tetrahydrofuran for 1h; Ambient temperature; Yield given; |
Conditions | Yield |
---|---|
With lithium chloride In N,N-dimethyl acetamide at 30℃; Pt anode, graphite cathode, sintered glass diaphragm, 1.3 V vs. SCE, 965 C; | A 95.8% B 2.8% |
With aluminum oxide; sodium chlorite; water; manganese(III) acetylacetonate In dichloromethane at 25℃; for 0.583333h; Product distribution; other solvents, inorganic support materials, times and temperatures, also without H2O; | A 85% B 8% |
With chlorine; natural kaolinitic clay In tetrachloromethane for 2h; Heating; | A 85% B 9% |
Conditions | Yield |
---|---|
With sodium carbonate In dichloromethane at 20℃; | 95% |
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h; | 51% |
With sodium hydroxide In N,N-dimethyl acetamide at 25℃; Rate constant; | |
With potassium carbonate at 130℃; |
Conditions | Yield |
---|---|
With nickel dichloride In N,N-dimethyl-formamide at 170℃; for 0.0833333h; microwave irradiation; | 94% |
With CuCl-alumina In various solvent(s) at 150℃; for 24h; | 54 % Chromat. |
With hydrogenchloride; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; oxygen In water; acetonitrile at 25℃; for 1.5h; Irradiation; | 53 %Chromat. |
3-chloro-4-methoxybenzyl alcohol
2-Chloroanisole
Conditions | Yield |
---|---|
With chlorobis(cyclooctene)-iridium(I) dimer; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; lithium chloride In water; 1,3,5-trimethyl-benzene at 170℃; for 18h; Schlenk technique; Inert atmosphere; | 91% |
Conditions | Yield |
---|---|
With layered double hydroxide - supported L-methionine at 180℃; for 6h; Autoclave; chemoselective reaction; | 90% |
With 1,8-diazabicyclo[5.4.0]undec-7-ene In N,N-dimethyl-formamide for 0.0583333h; microwave irradiation; | 85% |
With dimanganese decacarbonyl at 180℃; for 1h; | 2% |
With leucine intercalated Mg-Al layered double hydorxide at 180℃; for 6h; Autoclave; Green chemistry; chemoselective reaction; | 86 %Chromat. |
N-chloro-N-(4-methylphenyl)acetamide
methoxybenzene
A
4-chloromethoxybenzene
B
2-Chloroanisole
C
N-(2-chloro-4-methylphenyl)acetamide
D
4-Methylacetanilide
Conditions | Yield |
---|---|
at 110℃; for 12h; Mechanism; Orton Haloaniline Rearrangement; Inert atmosphere; Darkness; | A 82% B n/a C n/a D 87% |
Conditions | Yield |
---|---|
With 18-crown-6 ether; potassium carbonate at 150℃; for 2h; | 85% |
2-Chloroanisole
Conditions | Yield |
---|---|
In dimethyl sulfoxide Ambient temperature; | 84% |