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CAS No.: | 822-39-9 |
---|---|
Name: | 2-Chloro-1,3,2-dioxaphospholane |
Article Data: | 38 |
Molecular Structure: | |
Formula: | C2H4 Cl O2 P |
Molecular Weight: | 126.479 |
Synonyms: | Ethylenephosphorochloridite (6CI,7CI); Phosphorochloridous acid, cyclic ethylene ester(8CI); Ethylene glycol, cyclic phosphorochloridite (8CI);2-Chloro-1,3,2-dioxaphospholane; Cyclic O,O-ethylene phosphorochloridite;Cyclic ethylene chlorophosphite; Cyclic ethylene phosphorochloridite; Ethylenechlorophosphite; Ethylene glycol chlorophosphite |
EINECS: | 212-499-4 |
Density: | 1.422 |
Melting Point: | -28oC |
Boiling Point: | 117.4 °C at 760 mmHg 62 oC (20 mmHg) |
Flash Point: | 86 ºC |
Appearance: | clear colorless to slightly yellow liquid |
Hazard Symbols: | |
Risk Codes: | R14;R34 |
Safety: | S25;S8 |
Transport Information: | UN 3264 |
PSA: | 32.05000 |
LogP: | 1.49890 |
Conditions | Yield |
---|---|
With phosphorus trichloride In dichloromethane at 0℃; for 14h; | 92% |
With phosphorus trichloride In dichloromethane at 20℃; for 0.5h; Inert atmosphere; | 74.7% |
With phosphorus trichloride In dichloromethane at 20℃; for 3h; Inert atmosphere; | 67% |
ethylene glycol
A
1,1,6,6-tetrachloro-2,5-dioxa-1,6-diphosphahexane
B
2-chloro-1,3,2-dioxaphospholan
Conditions | Yield |
---|---|
With triethylamine; phosphorus trichloride at 45℃; Reagent/catalyst; | A 51.7% B n/a |
With phosphorus trichloride anfangs unter Luehlung,dann bei 60-70grad; |
2-methyl-[1,3,2]dioxarsolane
2-chloro-1,3,2-dioxaphospholan
Conditions | Yield |
---|---|
With phosphorus trichloride In benzene |
pyridine
diethyl ether
ethylene glycol
phosphorus trichloride
2-chloro-1,3,2-dioxaphospholan
dichloromethane
ethylene glycol
phosphorus trichloride
2-chloro-1,3,2-dioxaphospholan
diethyl ether
ethylene glycol
N,N-dimethyl-aniline
phosphorus trichloride
2-chloro-1,3,2-dioxaphospholan
ethylene glycol
phosphorus trichloride
A
1,1,6,6-tetrachloro-2,5-dioxa-1,6-diphosphahexane
B
2-chloro-1,3,2-dioxaphospholan
Conditions | Yield |
---|---|
anfangs unter Kuehlung, dann bei 60-70grad; |
2-chloro-1,3,2-dioxaphospholan
2-azido-1,3,2-dioxaphospholane
Conditions | Yield |
---|---|
With trimethylsilylazide at 0 - 5℃; for 3h; | 100% |
With (C2H5)3N*NH3 |
N-methylbenzamide
2-chloro-1,3,2-dioxaphospholan
Conditions | Yield |
---|---|
In diethyl ether Ambient temperature; | 97% |
2,3-Di(stearoyloxy)-1-propanthiol
2-chloro-1,3,2-dioxaphospholan
2-(2,3-Distearoyloxypropyl)-1,3,2-dioxaphospholan-2-sulfid
Conditions | Yield |
---|---|
With triethylamine In benzene for 3h; Ambient temperature; | 96% |
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IUPAC Name: 2-Chloro-1,3,2-dioxaphospholane
Synonyms of 1,3,2-Dioxaphospholane,2-chloro- (CAS NO.822-39-9): 2-Chloro-1,3,2-dioxaphospholane ; Ethylene chlorophosphite ; Ethylene glycol chlorophosphite
CAS NO: 822-39-9
Molecular Formula: C2H4ClO2P
Molecular Weight: 126.48
Molecular Structure:
EINECS: 212-499-4
H bond acceptors: 2
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 32.05 Å2
Flash Point: 24.8 °C
Enthalpy of Vaporization: 34.09 kJ/mol
Boiling Point: 117.4 °C at 760 mmHg
Vapour Pressure: 20.8 mmHg at 25°C
Storage temp: 2-8°C
Sensitive: Moisture Sensitive
Appearance: Clear Colourless Oil
SMILES: ClP1OCCO1
InChI: InChI=1/C2H4ClO2P/c3-6-4-1-2-5-6/h1-2H2
InChIKey: OLSFRDLMFAOSIA-UHFFFAOYAF
Std. InChI: InChI=1S/C2H4ClO2P/c3-6-4-1-2-5-6/h1-2H2
Std. InChIKey: OLSFRDLMFAOSIA-UHFFFAOYSA-N
Product Categories of 1,3,2-Dioxaphospholane,2-chloro- (CAS NO.822-39-9): Biochemistry;Nucleosides, Nucleotides & Related Reagents;Phosphorylating and Phosphorothioating Agents;Phosphorylation;Protecting Agents, Phosphorylating Agents & Condensing Agents;Synthetic Organic Chemistry;Phosphorylating and Phosphitylating Agents
1,3,2-Dioxaphospholane,2-chloro- (CAS NO.822-39-9) is used as highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs.
Hazard Codes: C
Risk Statements: 14-34-37
R14 : Reacts violently with water.
R34: Causes burns.
R37: Irritating to respiratory system
Safety Statements: 8-25-26-36/37/39-45
S8: Keep container dry.
S25: Avoid contact with eyes.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3264 8/PG 2
WGK Germany: 3
F: 1-10
HazardClass: 8
PackingGroup: II
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Water Reactive. Combustible liquid.
Extinguishing Media: Do NOT use water directly on fire. Use foam, dry chemical, or carbon dioxide.
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Storage: Keep 1,3,2-Dioxaphospholane,2-chloro- (CAS NO.822-39-9) away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Keep under a nitrogen blanket. Keep refrigerated. (Store below 4°C/39°F.)