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CAS No.: | 63-05-8 |
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Name: | Androstenedione |
Molecular Structure: | |
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Formula: | C19H26O2 |
Molecular Weight: | 286.414 |
Synonyms: | 17-Ketotestosterone;3,17-Dioxoandrost-4-ene;4-Androstene-3,17-dione;Androstenedione;Fecundin;NSC 9563;SKF 2170;D4-Androstene-3,17-dione;Androstenedione;4-Androstenedione; |
EINECS: | 200-554-5 |
Density: | 1.11 g/cm3 |
Melting Point: | 170-171 °C(lit.) |
Boiling Point: | 431.4 °C at 760 mmHg |
Flash Point: | 161.1 °C |
Solubility: | 57.28mg/L(25 oC) |
Appearance: | white to off-white solid |
Hazard Symbols: |
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Risk Codes: | 40 |
Safety: | 22-24/25-36 |
PSA: | 34.14000 |
LogP: | 4.08740 |
Conditions | Yield |
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With Jones reagent In acetone at 0℃; Jones Oxidation; | 100% |
With oxygen; nitrosonium tetrafluoroborate In dichloromethane at 20℃; for 4h; | 99% |
With N-chloro-succinimide; dodecyl methyl sulfide; triethylamine In toluene at -40℃; for 16h; Corey-Kim oxidation; | 97% |
3-hydroxy-5-androsten-17-one
Androstenedione
Conditions | Yield |
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With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; ferric nitrate In ethyl acetate at 0℃; for 65h; Reagent/catalyst; | 100% |
Conditions | Yield |
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In water; acetonitrile at 20℃; Electrochemical reaction; | 99% |
With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide In dichloromethane; acetonitrile for 0.75h; | 95% |
With chromium(VI) oxide; acetic acid |
Conditions | Yield |
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With hydrogenchloride In ethanol; water at 40℃; for 2h; pH=3; Temperature; Green chemistry; | 98.6% |
With sulfuric acid; water; silica gel In toluene for 2h; | 92% |
Multi-step reaction with 4 steps 1: hydrogenchloride / water; acetone / pH 1-6 2: potassium tert-butylate / tetrahydrofuran / Inert atmosphere; Reflux 3: tetrahydrofuran / Acidic conditions 4: sodium hydrogencarbonate; ruthenium trichloride; Oxone / ethyl acetate; acetonitrile; water / -20 - 30 °C View Scheme |
Conditions | Yield |
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With calcium hypochlorite; acetic acid In ethyl acetate at 30℃; for 1h; Temperature; Green chemistry; | 98.5% |
(8R,9S,10R,13S,14S,17S)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[α]phenanthrene-3,17-diol
Androstenedione
Conditions | Yield |
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With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide In dichloromethane for 0.5h; | 98% |
With 9-fluorenone; oxygen In dimethyl sulfoxide at 20℃; Irradiation; | 72% |
Conditions | Yield |
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With potassium hydroxide In methanol; water Ambient temperature; | 97% |
With sodium hydroxide In methanol; water at 25℃; | |
With sodium hydroxide; 3-oxo-Δ5-steroid isomerase In methanol; water Rate constant; pH 5.0 to 5.1; |
3-cycloethylenedithio-17-cycloethylenedioxy-androst-4-ene
Androstenedione
Conditions | Yield |
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With silica gel; copper(II) sulfate In benzene at 80℃; for 5h; | 90% |
Conditions | Yield |
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aluminum oxide; copper In toluene at 60℃; | A 12% B 88% |
Conditions | Yield |
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In water; acetonitrile at 20℃; Electrochemical reaction; | 86% |
With ammonium hydroxide; iodine In water; acetonitrile at 50℃; for 24h; | 78% |
With manganese(IV) oxide In chloroform for 4h; Heating; | 67.6% |
The Androstenedione is an organic compound with the formula C19H26O2. The IUPAC name of this chemical is (8R,9S,10R,13S,14S)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione. With the CAS registry number 63-05-8, it is also named as 4-Androsten-3,17-dione. The product's categories are Pharmaceutical Intermediates; Steroids; Metabolites & Impurities. Besides, it is a white to off-white solid, which should be stored in a closed place. It is used for biochemical studies.
Physical properties about Androstenedione are: (1)ACD/LogP: 2.90; (2)ACD/LogD (pH 5.5): 2.9; (3)ACD/LogD (pH 7.4): 2.9; (4)ACD/BCF (pH 5.5): 93.64; (5)ACD/BCF (pH 7.4): 93.64; (6)ACD/KOC (pH 5.5): 896.96; (7)ACD/KOC (pH 7.4): 896.96; (8)#H bond acceptors: 2; (9)Polar Surface Area: 34.14 Å2; (10)Index of Refraction: 1.551; (11)Molar Refractivity: 81.71 cm3; (12)Molar Volume: 255.8 cm3; (13)Polarizability: 32.39×10-24cm3; (14)Surface Tension: 42.6 dyne/cm; (15)Density: 1.11 g/cm3; (16)Flash Point: 161.1 °C; (17)Enthalpy of Vaporization: 68.71 kJ/mol; (18)Boiling Point: 431.4 °C at 760 mmHg; (19)Vapour Pressure: 1.2E-07 mmHg at 25°C.
Preparation: this chemical can be prepared by 17-hydroxy-androst-4-en-3-one. This reaction will need reagent CrO3 and acetic acid.
Uses of Androstenedione: it can be used to produce 5,17-dioxo-3,5-seco-A-nor-androstan-3-oic acid. It will need reagent KMnO4 and acetone.
When you are using this chemical, please be cautious about it as the following:
It has limited evidence of a carcinogenic effect. When you are using it, wear suitable protective clothing, do not breathe dust and avoid contact with skin and eyes.
You can still convert the following datas into molecular structure:
(1)SMILES: O=C4/C=C3/CC[C@@H]2[C@H](CC[C@@]1(C(=O)CC[C@H]12)C)[C@@]3(C)CC4
(2)InChI: InChI=1/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1
(3)InChIKey: AEMFNILZOJDQLW-QAGGRKNEBJ
(4)Std. InChI: InChI=1S/C19H26O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h11,14-16H,3-10H2,1-2H3/t14-,15-,16-,18-,19-/m0/s1
(5)Std. InChIKey: AEMFNILZOJDQLW-QAGGRKNESA-N