Abnormal metabolites of isoleucine in a patient with propionyl-CoA carboxylase deficiency

Sweetman,Weyler,Nyhan,de Cespedes,Loria,Estrada

, p. 198 - 207 (1978)

A number of previously unrecognized abnormal metabolites have been identified and quantitated in the urine of a patient with an inherited deficiency of propionyl CoA carboxylase. These included the isoleucine metabolites 2 methyl 3 hydroxybutyric acid and 2 methylacetoacetic acid. The isomers 3 hydroxyvaleric acid and 3 oxovaleric acid were found, which may be products of the condensation of propionyl CoA with acetyl CoA catalyzed by 3 oxoacyl CoA thiolases. Following a load of isoleucine, 2 methylbutyrylglycine was identified. This metabolite has not previously been observed in man.

Ives,Kerlogue

, p. 1362 (1940)

Photolysis and photocatalysis of ibuprofen in aqueous medium: Characterization of by-products via liquid chromatography coupled to high-resolution mass spectrometry and assessment of their toxicities against Artemia Salina

Da Silva, Julio Cesar Cardoso,Teodoro, Janaina Aparecida Reis,Afonso, Robson Jose De Cassia Franco,Aquino, Sergio Francisco,Augusti, Rodinei

, p. 145 - 153 (2014/02/14)

The degradation of the pharmaceutical compound ibuprofen (IBP) in aqueous solution induced by direct photolysis (UV-A and UV-C radiation) and photocatalysis (TiO2/UV-A and TiO2/UV-C systems) was evaluated. Initially, we observed that whereas photocatalysis (both systems) and direct photolysis with UV-C radiation were able to cause an almost complete removal of IBP, the mineralization rates achieved for all the photodegradation processes were much smaller (the highest value being obtained for the TiO 2/UV-C system: 37.7%), even after an exposure time as long as 120 min. Chemical structures for the by-products formed under these oxidative conditions (11 of them were detected) were proposed based on the data from liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) analyses. Taking into account these results, an unprecedented route for the photodegradation of IBP could thus be proposed. Moreover, a fortunate result was achieved herein: tests against Artemia salina showed that the degradation products had no higher ecotoxicities than IBP, which possibly indicates that the photocatalytic (TiO2/UV-A and TiO2/UV-C systems) and photolytic (UV-C radiation) processes can be conveniently employed to deplete IBP in aqueous media. Copyright

Process for production of N-acyl-α-amino acids

-

, (2008/06/13)

A process for the production of an N-acyl-α-amino acid represented by the general formula STR1 wherein R1, R2, R3 and R4, independently from each other, represent a hydrogen atom, an alkyl or cycloalkyl group which may be substituted, or an aryl or heteroaromatic group selected from the group consisting of furyl, pyrrolyl, pyridinyl, thienyl and indolyl which may be substituted, which comprises reacting an oxirane represented by the general formula STR2 wherein R1 and R2 are as defined above, an amide compound represented by the general formula wherein R3 and R4 are as defined above, and carbon monoxide in the presence of hydrogen, a cobalt-containing catalyst, and a promoter composed of a compound containing a metal selected from Groups I, II, III and IV of the periodic table.