1119-29-5Relevant articles and documents
Photoinduced remote regioselective radical alkynylation of unactivated C-H bonds
Hu, Qu-Ping,Liu, Yong-Ze,Liu, Yu-Tao,Pan, Fei
supporting information, p. 2295 - 2298 (2022/02/25)
A method for the remote regioselective alkynylation of unactivated C(sp3)-H bonds in diverse aliphatic amides by photogenerated amidyl radicals has been developed. The site-selectivity is dominated via a 1,5-hydrogen atom transfer (HAT) process of the amide. Mild reaction conditions and high regioselectivity are demonstrated in this methodology.
NURR1 RECEPTOR MODULATORS
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Paragraph 0646; 0996-0998, (2020/09/08)
Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.
A method for preparing DL-leucine (by machine translation)
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Paragraph 0009, (2017/03/14)
The invention discloses a method for preparing DL-leucine. The method of the invention first through ethanol, acetamide, ethanol sodium and isobutyl bromide reaction, reaction solution distillation recovery ethanol, distillation residues hot-melt, filtering, cooling to crystallize, shall be 2-isobutyl-acetamide; and then the 2-isobutyl-acetamide react with sodium hypochlorite, reaction solution distillation recovery chcl, distillation residual the toluene-P-sulfonic acid reaction, the reaction liquid filtering, cooling to crystallize, shall be leucine paratoluene sulfonic acid; leucines toluene-P-sulfonic acid with sodium hydroxide reaction, and the re-adjustment to pH 6-6.5 DL-leucine can be obtained. The invention chemical synthetic mild reaction conditions, the low requirements for the equipment, production cycle is short, with little investment, low cost; relatively high yield, there are few by-products, can be produced in large quantities, which is beneficial for industrial; acetamide can be formed by preparing ketene dimer, easily available raw materials. (by machine translation)
