117632-35-6Relevant articles and documents
HETEROCYCLIC AMIDES AS ROCK INHIBITORS
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Page/Page column 80, (2011/10/03)
The present invention relates to new kinase inhibitors of formula (I), more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.
Haloacetylated Enol Ethers: 4. Synthesis of 4-Trihalomethyl-2-methylthiopyrimidines
Madruga, Claudia da C.,Clerici, Edflia,Martins, Marcos A. P.,Zanatta, Nilo
, p. 735 - 738 (2007/10/02)
The synthesis of a series of 5- and 6-substituted 4-trihalomethyl-2-methylthiopyrimidines, prepared from the cyclocondensation reaction of β-alkoxyvinyl trichloromethyl ketones with 2-methyl-2-thiopseudourea sulfate, are reported.A systematic study to find the best reation conditions werre carried out.
STEREOSELECTIVE SYNTHESES OF 2-SUBSTITUTED PERHYDROFUROFURANS
Vader, Jan,Koopmans, Rimco,Groot, Aede De,Veldhuizen, Albertus van,Kerk, Sies van der
, p. 2663 - 2674 (2007/10/02)
New reagents for the stereoselective synthesis of 2-substituted perhydrofurofurans are described.In the successful approach towards the latter compounds, the key steps were the addition of a monolithio-2α-methoxy-3β-perhydrofuran to an aldehyde and a dilithio-2α-methoxy-3β-perhydrofuran to a carboxyl derivative, respectively.The structures and conformations of the 2-tert-butyl- and 2-isopropylperhydrofurofurans were examined by means of (1)H-NMR double resonance and the 2D-NOE spectroscopy.
