1214-54-6Relevant articles and documents
Ionic liquid-mediated knoevenagel condensation of Meldrum's acid and aldehydes
Darvatkar, Nitin B.,Deorukhkar, Amol R.,Bhilare, Sachin V.,Salunkhe, Manikrao M.
, p. 3043 - 3051 (2006)
A simple, efficient, and green protocol for Knoevenagel condensation of Meldrum's acid and aldehydes in ionic liquid at room temperature without any catalyst is described. The reaction has been performed in different ionic liquids. The enhancement in the
Organocatalysed multicomponent synthesis of pyrazolidinones: Meldrum's acid approach
Pair, Etienne,Berini, Christophe,No?l, Romain,Sanselme, Morgane,Levacher, Vincent,Brière, Jean-Fran?ois
, p. 10218 - 10221 (2014)
We discovered a novel organocatalysed multicomponent domino Knoevenagel-aza-Michael-cyclocondensation reaction leading to an unprecedented straightforward synthesis of 1,5-diazabicyclo[3.3.0]octane-2,6-diones. The specific capability of the (DHQ)2PHAL organocatalyst in this process was also highlighted to eventually furnish the corresponding bicyclopyrazolidinones with up to 96:4 er. This journal is the Partner Organisations 2014.
GaCl3-catalyzed insertion of diazene derivatives into the cyclopropane ring
Korotkov, Vadim S.,Larionov, Oleg V.,Hofmeister, Anja,Magull, Joerg,De Meijere, Armin
, p. 7504 - 7510 (2007)
(Chemical Equation Presented) GaCl3 has been found to efficiently catalyze the formal cycloadditions of diazene derivatives 6 onto 2-arylcyclopropane-1,1-dicarboxylates 5, giving rise to the pyrazolidine derivatives 7. The insertion into the cy
Knoevenagel condensation of aldehydes with cyclic active methylene compounds in water
Ren, Zhongjiao,Cao, Weiguo,Tong, Weiqi,Jing, Xiuping
, p. 1947 - 1952 (2002)
A new route of Knoevenagel condensation of aromatic aldehydes with Meldrum's acid, barbituric acid and dimedone in the presence of cetyltrimethyl ammonium bromide at room temperature in water is described.
Difluoromethylene phosphabetaine as an equivalent of difluoromethyl carbanion
Levin, Vitalij V.,Trifonov, Alexey L.,Zemtsov, Artem A.,Struchkova, Marina I.,Arkhipov, Dmitry E.,Dilman, Alexander D.
, p. 6256 - 6259 (2014)
A method for nucleophilic difluoromethylation of reactive Michael acceptors, aldehydes, and azomethines is described. The reaction is performed using the readily available and air-stable reagent difluoromethylene phosphabetaine. The process involves inter
Kinetic studies of condensation of aromatic aldehydes with Meldrum's acid
Medien
, p. 1320 - 1326 (2002)
The condensation reaction of Meldrum's acid with aromatic aldehydes in the presence of a catalyst has been investigated spectrophotometrically at 25-50 °C. The reaction follows overall second order kinetics, first order in each of the reactants. Electron-
Cage-catalyzed Knoevenagel condensation under neutral conditions in water
Murase, Takashi,Nishijima, Yuki,Fujita, Makoto
, p. 162 - 164 (2012)
A cationic coordination cage dramatically accelerates the Knoevenagel condensation of aromatic aldehydes in water under neutral conditions. The addition of a nucleophile to the aldehyde to generate anionic intermediates seems to be facilitated by the cationic environment of the cavity. The products are ejected from the cage as a result of the host-guest size discrepancy. As a result, the condensation is promoted by a catalytic amount of the cage.
Bentonite catalyzed an efficient and green synthesis of arylidene meldrum's acid derivatives in aqueous media
Yahyazadehfar, Mahdieh,Ahmadi, Sayed Ali,Sheikhhosseini, Enayatollah,Ghazanfari, Dadkhoda
, p. 513 - 519 (2021/07/25)
In the present paper, a simple, highly efficient, and environmentally friendly protocol was proposed for the Knoevenagel condensation reaction of aromatic aldehydes using Meldrum’s acid (2,2-dimethyl-4,6-dioxo-1,3-dioxane) with bentonite as an available n
Preparation of mono-substituted malonic acid half oxyesters (SMAHOs)
Condon, Sylvie,Le Gall, Erwan,Pichon, Christophe,Presset, Marc,Xavier, Tania
supporting information, p. 2085 - 2094 (2021/09/02)
The use of mono-substituted malonic acid half oxyesters (SMAHOs) has been hampered by the sporadic references describing their preparation. An evaluation of different approaches has been achieved, allowing to define the best strategies to introduce diversity on both the malonic position and the ester function. A classical alkylation step of a malonate by an alkyl halide followed by a monosaponification gave access to reagents bearing different substituents at the malonic position, including functionalized derivatives. On the other hand, the development of a monoesterification step of a substituted malonic acid derivative proved to be the best entry for diversity at the ester function, rather than the use of an intermediate Meldrum acid. Both these transformations are characterized by their simplicity and efficiency, allowing a straightforward access to SMAHOs from cheap starting materials.
