123005-17-4Relevant articles and documents
A Fe(III)/NaBH4-Promoted Free-Radical Hydroheteroarylation of Alkenes
Liang, Bingyu,Wang, Qinglong,Liu, Zhong-Quan
, p. 6463 - 6465 (2017)
A free-radical-mediated intermolecular hydroheteroarylation of simple alkenes was developed. Through simply mixing heteroarenes, alkenes, Fe(III), and NaBH4 at 0 °C together, a wide range of alkylated heteroarenes could be afforded in moderate to excellent yields within 1 h.
Synthesis method of alkylated quinoline compound
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Paragraph 0056-0057, (2021/06/13)
The invention relates to a synthesis method of an alkylated quinoline compound. According to the method, under the irradiation of an ultraviolet LED lamp, in the presence of a catalyst, an acid additive and a solvent, the alkylated quinoline and the deriv
Visible-light-mediated photoredox minisci C-H alkylation with alkyl boronic acids using molecular oxygen as an oxidant
Dong, Jianyang,Yue, Fuyang,Song, Hongjian,Liu, Yuxiu,Wang, Qingmin
supporting information, p. 12652 - 12655 (2020/11/02)
Herein, we report a protocol for direct visible-light-mediated Minisci C-H alkylation reactions of heteroarenes with alkyl boronic acids using molecular oxygen as the sole oxidant. This mild protocol uses an inexpensive, green oxidant; permits efficient functionalization of various N-heteroarenes with a broad range of primary and secondary alkyl boronic acids; and is scalable to the gram level. We demonstrated the practicality and sustainability of the protocol by preparing or functionalizing several pharmaceuticals and natural products.
Terminal-oxidant-free photocatalytic C-H alkylations of heteroarenes with alkylsilicates as alkyl radical precursors
Ikarashi, Gun,Morofuji, Tatsuya,Kano, Naokazu
, p. 10006 - 10009 (2020/09/23)
We report the photocatalytic C-H alkylations of heteroarenes with alkylsilicates bearing C,O-bidentate ligands under acidic conditions. Irradiation of heteroaromatics in the presence of the silicates and trifluoroacetic acid produced the corresponding alkylated compounds. The present reaction system does not require any terminal oxidant although the reaction seems to be a formal oxidation reaction. This study demonstrates that alkylsilicates can be used in photocatalytic radical chemistry under acidic conditions.
