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172478-10-3

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172478-10-3 Usage

Description

N-BENZYL-D-PROLINE ETHYL ESTER is a chemical compound derived from the amino acid D-proline, featuring a benzyl group attached to the nitrogen atom. It is utilized in medicinal chemistry and drug development due to its unique chemical structure, which allows for specific interactions with biological systems, making it a valuable asset in the synthesis of biologically active molecules and the development of pharmaceuticals.

Uses

Used in Medicinal Chemistry:
N-BENZYL-D-PROLINE ETHYL ESTER is used as a building block for the synthesis of biologically active molecules, contributing to the advancement of pharmaceuticals. Its distinctive structure enables targeted interactions with biological systems, facilitating the creation of new therapeutic agents.
Used in Drug Development:
In the pharmaceutical industry, N-BENZYL-D-PROLINE ETHYL ESTER is employed as a key component in the design and development of innovative drugs. Its potential to engage with biological targets in specific ways aids researchers in formulating more effective treatments and medicines.

Check Digit Verification of cas no

The CAS Registry Mumber 172478-10-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,2,4,7 and 8 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 172478-10:
(8*1)+(7*7)+(6*2)+(5*4)+(4*7)+(3*8)+(2*1)+(1*0)=143
143 % 10 = 3
So 172478-10-3 is a valid CAS Registry Number.
InChI:InChI=1/C14H19NO2/c1-2-17-14(16)13-9-6-10-15(13)11-12-7-4-3-5-8-12/h3-5,7-8,13H,2,6,9-11H2,1H3/t13-/m1/s1

172478-10-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl (2R)-1-benzylpyrrolidine-2-carboxylate

1.2 Other means of identification

Product number -
Other names (R)-1-BENZYL-PYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:172478-10-3 SDS

172478-10-3Relevant articles and documents

-

Hata,Watanabe

, p. 4659 (1972)

-

Reactions of amines and hydrazides derived from L-proline with dialkyl dicyanofumarates

Mloston, Grzegorz,Pieczonka, Adam M.,Wroblewska, Aneta,Linden, Anthony,Heimgartner, Heinz

, p. 343 - 356 (2013/08/15)

The reaction of prolinamine derivatives (8a,b) and dialkyl dicyanofumarates (1) in dichloromethane at room temperature leads to the optically active enamines (10). Whereas products (10) in the case of 1-benzyl prolinamine (8a) are stable compounds, the corresponding enamines obtained from the non-protected prolinamine (8b) smoothly undergo a cyclocondensation at room temperature to give perhydropyrrolo[1,2-a]pyrazine derivatives (11). The molecular structure of 11a was established by X-Ray crystallography. In analogy to 8a, 1-benzyl prolinehydrazide (9a) and 1b in dichloromethane react to yield the enehydrazine (12b). On the other hand, the reaction of 9a and 1 in methanol at room temperature leads to the corresponding dialkyl 3-amino-1H-pyrazole- 4,5-dicarboxylates (13) and methyl 1-benzylprolinate (14b) Via a stepwise mechanism. The analogous reaction was observed between a 3-oxidoimidazole-4- carbohydrazide (15) and 1b.

One-carbon ring expansion of azetidines via ammonium ylide [1,2]-shifts: A simple route to substituted pyrrolidines

Bott, Tina M.,Vanecko, John A.,West

supporting information; scheme or table, p. 2832 - 2836 (2009/08/15)

Simple N-substituted azetidines were heated with diazocarbonyl compounds in the presence of catalytic Cu(acac)2 to furnish substituted pyrrolidines via Stevens [1,2]-shift. In all but two examples, complete selectivity was seen for ring expansion rather than migration of the other exocyclic group on the azetidinium nitrogen. The two exceptions, observed with ylides substituted with two carbonyl groups and lacking a stabilizing group at the 2-position of the azetidine, underwent exocyclic benzyl migration in preference to ring expansion.

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