18440-58-9Relevant articles and documents
Synthesis and cytotoxic activity study of novel 2-(Aryldiazenyl)-3-methyl-1h-benzo[g]indole derivatives
Abdel-Jalil, Raid J.,Adham, Sirin A. I.,Arafeh, Manar M.,Moghadam, Ebrahim Saeedian,Stoll, Raphael
, (2021/07/26)
A novel series of 2-(aryldiazenyl)-3-methyl-1H-benzo[g]indole derivatives (3a–f) were prepared through the cyclization of the corresponding arylamidrazones, employing polyphosphoric acid (PPA) as a cyclizing agent. All of the compounds (3a–f) were characterized using1H NMR,13C NMR, MS, elemental analysis, and melting point techniques. The synthesized compounds were evaluated for cytotoxic activity against diverse human cancer cell lines by the National Cancer Institute. While all of the screened compounds were found to be cytotoxic at a 10 μM concentration, two of them (2c) and (3c) were subjected to five dose screens and showed a significant cytotoxicity and selectivity.
New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study
AboulMagd, Asmaa M.,Nemr, Mohamed T. M.
, (2020/08/06)
A new series of triazolopyrimidines and thiazolopyrimidine hydrobromides was designed and prepared as topoisomerase II inhibitors. Screening of all synthesized compounds was carried out by the National Cancer Institute (NCI) of USA. Activity against 60 hu
Synthesis and structure-activity relationship; exploration of some potent anti-cancer phenyl amidrazone derivatives
Habashneh, Almeqdad Y.,El-Abadelah, Mustafa M.,Bardaweel, Sanaa K.,Taha, Mutasem O.
, p. 468 - 477 (2018/07/25)
Background: Amidrazones have been reported to have significant anti-tumor properties against several cancer cell lines. Objectives: The current project aims to profile the structure-anticancer activity relationship of phenyl-amidrazons. Methods: Fifteen p
