18819-66-4Relevant articles and documents
N-heterocyclic carbene catalyzed cyclization cascades of 3-halopropenals and arylnitroso compounds to 2,3-disubstituted isoxazol-5(2 H)-ones
Yao, Weijun,Bian, Ming,Wang, Gang,Ma, Cheng
supporting information; experimental part, p. 1998 - 2002 (2011/08/05)
An NHC-catalyzed annulation reaction of 3-halopropenals with nitrosobenzene derivatives, providing access to 2,3-disubstituted isoxazol-5(2H)-ones under mild conditions is described. This procedure represents a metal-free approach to the alternative equiv
Hydrochlorination of 2,3-acetylenic acids with thionyl chloride in dimethylformamide
Urdaneta, Neudo A.,Herrera, Julio C.,Salazar, Jose,Lopez, Simon E.
, p. 3003 - 3009 (2007/10/03)
The reaction of 2,3-acetylenic acids (1a-d) with thionyl chloride in DMF under mild conditions gave E,Z-3-chloro-2-alkenoic acids (2a-d) or esters (3a-d) depending on treating the reaction mixture with either water or alcohols.