100612-87-1Relevant academic research and scientific papers
Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin
Hartmann, Caroline E.,Gross, Patrick J.,Nieger, Martin,Braese, Stefan
supporting information; experimental part, p. 5059 - 5062 (2010/04/04)
Studies towards the synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin are reported. The synthetic approach features an organocatalytic access to the α,α-disubstituted amino acid unit and results in the synthesis of an advanced inter
Syntheses of isochromane analogues of the michellamines and korupensamines
De Koning, Charles B.,Michael, Joseph P.,Van Otterlo, Willem A.L.
, p. 799 - 811 (2007/10/03)
Syntheses of the oxygen analogues 6, 7 and 8 of the michellamines 1 and korupensamines 2 are described. Racemic 5-iodo-6,8-dimethoxy-trans-1,3-dimethylisochromane 10 was synthesised in eleven steps from 2,4-dimethoxybenzaldehyde in an overall yield of 51%
Synthesis of an isochroman analogue of the michellamines
De Koning, Charles B.,Michael, Joseph P.,Van Otterlo, Willem A.L.
, p. 3037 - 3040 (2007/10/03)
The synthesis of racemic 5-iodo-6,8-dimethoxy-1,3-trans- dimethylisochroman (16) in eleven steps from 2,4-dimethoxybenzaldehyde is outlined. Compound (16) was coupled by means of Suzuki methodology with 4- isopropoxy-5-methoxy-7-methylnaphthaleneboronic a
An investigation into the electronic effects of substituents at the 6-position on the biological activity of isochromanquinones
Green, Ivan R.,De Koning, Charles B.,Hugo, Victor I.
, p. 112 - 119 (2007/10/03)
Three isochromanquinones 10, 11 and 12 were synthesised in order to determine the effect of electronic effects of groups at the 6-position on the biological activity of these compounds.
