100612-88-2Relevant academic research and scientific papers
Towards an asymmetric synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin
Hartmann, Caroline E.,Gross, Patrick J.,Nieger, Martin,Braese, Stefan
supporting information; experimental part, p. 5059 - 5062 (2010/04/04)
Studies towards the synthesis of the bacterial peptide deformylase (PDF) inhibitor fumimycin are reported. The synthetic approach features an organocatalytic access to the α,α-disubstituted amino acid unit and results in the synthesis of an advanced inter
The synthesis of isochroman-4-ols and isochroman-3-ols: Models for naturally occurring benzo[g]isochromanols
De Koning, Charles B,Green, Ivan R,Michael, Joseph P,Oliveira, José R
, p. 9623 - 9634 (2007/10/03)
The synthesis of isochromanes containing hydroxy substituents at the 4- and 3-positions has been achieved. The key step for the synthesis of the isochroman-4-ols entailed an oxidative mercury mediated ring closure of 2-(prop-1-enyl)phenylmethanol derivati
Syntheses of isochromane analogues of the michellamines and korupensamines
De Koning, Charles B.,Michael, Joseph P.,Van Otterlo, Willem A.L.
, p. 799 - 811 (2007/10/03)
Syntheses of the oxygen analogues 6, 7 and 8 of the michellamines 1 and korupensamines 2 are described. Racemic 5-iodo-6,8-dimethoxy-trans-1,3-dimethylisochromane 10 was synthesised in eleven steps from 2,4-dimethoxybenzaldehyde in an overall yield of 51%
Synthesis of an isochroman analogue of the michellamines
De Koning, Charles B.,Michael, Joseph P.,Van Otterlo, Willem A.L.
, p. 3037 - 3040 (2007/10/03)
The synthesis of racemic 5-iodo-6,8-dimethoxy-1,3-trans- dimethylisochroman (16) in eleven steps from 2,4-dimethoxybenzaldehyde is outlined. Compound (16) was coupled by means of Suzuki methodology with 4- isopropoxy-5-methoxy-7-methylnaphthaleneboronic a
An investigation into the electronic effects of substituents at the 6-position on the biological activity of isochromanquinones
Green, Ivan R.,De Koning, Charles B.,Hugo, Victor I.
, p. 112 - 119 (2007/10/03)
Three isochromanquinones 10, 11 and 12 were synthesised in order to determine the effect of electronic effects of groups at the 6-position on the biological activity of these compounds.
