1016-41-7

Usage

Uses

Used in Organic Synthesis:
5-Ethoxy-3-methyl-1-phenylpyrazole is used as a building block or intermediate in the synthesis of more complex organic compounds. Its versatile structure allows for further functionalization and modification, making it a valuable component in the development of new organic molecules.
Used in Pharmaceutical Research:
5-Ethoxy-3-methyl-1-phenylpyrazole is used as a starting material or scaffold in the design and synthesis of new pharmaceutical agents. Its potential activity and interactions with biological systems make it a promising candidate for the development of novel drugs with therapeutic applications.
Used in Drug Development:
5-Ethoxy-3-methyl-1-phenylpyrazole may have potential uses in the development of new drugs due to its activity and interactions with biological systems. Its unique structure and properties can be exploited to design drugs with specific targets and mechanisms of action, potentially leading to the discovery of new therapeutic agents.
Used in Agrochemical Development:
5-Ethoxy-3-methyl-1-phenylpyrazole may also have potential applications in the development of new agrochemicals, such as pesticides or herbicides. Its unique structure and properties could be utilized to create compounds with improved efficacy, selectivity, and environmental compatibility.
However, it is important to note that further research and testing are necessary to fully understand the potential benefits and risks associated with the use of 5-Ethoxy-3-methyl-1-phenylpyrazole in these applications.

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-63-0 phenylhydrazine 
• 6078-46-2 ethyl 3-(2-phenylhydrazono)butanoate 
• 75-36-5 acetyl chloride 
• 108-86-1 bromobenzene 
• 60-29-7 diethyl ether 
• 574-61-8 benzophenone N-phenylhydrazone 

Downstream Products

• 284672-25-9 5-Ethoxy-3-methyl-1-phenyl-4-phthalimidothiopyrazole 
• 151751-01-8 (3-methyl-1-phenyl-5-ethoxypyrazol-4-yl)phosponous bis(diethylamide) 
• 151750-96-8 (3-methyl-1-phenyl-5-ethoxypyrazol-4-yl)phosponous bis(dimethylamide) 
• 89-25-8 edaravone 
• 174811-61-1 C₁₂H₁₃Br₂N₂OP 
• 3614-49-1 1-ethyl-5-methyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one 
• 19735-89-8 3-methyl-1-phenylpyrazolin-5(4H)-one 
• 10252-46-7 3-methyl-1-phenyl-4,5-dihydropyrazole 
• 60-80-0 antipyrine 

Relevant academic research and scientific papers

Scale-Up of a Continuous Manufacturing Process of Edaravone

Edaravone belongs to a class of brain-protective agents, which can scavenge free radicals. To reduce impurities and improve the yield, a continuous flow production process of edaravone was developed. The synthesis is continuously carried out in two steps. The throughput can reach 11.328 kg/day and the purity of the final product is 99.95%, which are in accordance with the needs of production. This is an efficient and quick production process suitable for industrial production.

Transformations of phenylhydrazones of dialkyl 2-oxo-propane-1,3- dicarboxylate and of ethyl acetoacetate in concentrated sulfuric acid

The hydrazones 3a,b, prepared from phenylhydrazine (1) and dialkyl 2-oxopropane-1,3-dicarboxylate (2a,b) were converted in concentrated sulfuric acid at -5 °C into a mixture of alkyl (3-carboxyindol-2-yl)acetates (5a,b), and ethyl (5-ethoxy-1-phenyl-1H-pyrazol-3-yl)acetate 6. The hydrazone 8, prepared from 1 and ethyl acetoacetate (7) was transformed under the same conditions into a mixture of five compounds: ethyl 2-methylindol-3-carboxylate (9), 2-methylindol-3-carboxylic acid (10), 2-methylindol (11), 5-ethoxy-3-methyl-1-phenyl-1H-pyrazole (12), and 3-methyl-1-phenyl-1H-pyrazol-5- one (13).

ZnO: An Ecofriendly, Green Nano-catalyst for the Synthesis of Pyrazole Derivatives under Aqueous Media

An efficient nano ZnO catalyzed green protocol for the synthesis of pyrazol derivatives by condensation of different substituted phenyl hydrazines/semicarbazide/thiosemicarbazide with 1,3-diketone/ketoester at ambient temperature has been achieved. ZnO na

2 (Oxa) as a heterogeneous recyclable catalyst: Synthesis of pyrazoles under mild reaction conditions

We developed a novel and highly efficient protocol for the synthesis of important pyrazole derivatives by using some 1,3-dicarbonyl compounds and phenyl hydrazines via a one-pot protocol. As a recyclable heterogeneous catalyst, we used [Ce(l-Pro)2]2 (Oxa). In addition, the catalyst is recyclable, the proline is economically viable and readily available in both enantiomeric forms and the catalyst is insoluble in almost all solvents and may be easily filtered off from the reaction medium. Moreover, this new synthetic protocol features high conversion, short reaction times, a straightforward procedure and cleaner reaction profiles.

Room-temperature synthesis of pyrazoles, diazepines, β-enaminones, and β-enamino esters using silica-supported sulfuric acid as a reusable catalyst under solvent-free conditions

Silica-supported sulfuric acid (H2SO4·SiO2) has been utilized as a heterogeneous recyclable catalyst for a highly efficient regio- and chemoselective condensation of hydrazines/hydrazides, diamines, and primary amines with various β-dicarbonyl compounds at room temperature to afford pyrazoles, diazepines, and β-enaminones/β-enamino esters under solvent-free conditions within 5-15 min. Copyright Taylor & Francis Group, LLC.

Synthesis of pyrazoles, diazepines, enaminones, and enamino esters using 12-tungstophosphoric acid as a reusable catalyst in water

12-Tungstophosphoric acid (H3PW12O40) is found to be an efficient and recyclable catalyst in promoting a chemo- and regioselective condensation of hydrazines/hydrazides, diamines, and primary amines with various 1,3-dicarbonyl compounds in pure water at room temperature to afford pyrazoles, diazepines, and enaminones/enamino esters, respectively, in high yields. Georg Thieme Verlag Stuttgart.

Greener and rapid access to bio-active heterocycles: room temperature synthesis of pyrazoles and diazepines in aqueous medium

An expeditious room temperature synthesis of pyrazoles and diazepines by condensation of hydrazines/hydrazides and diamines with various 1,3-diketones is described. This greener protocol was catalyzed by polystyrene supported sulfonic acid (PSSA) and proceeded efficiently in water in the absence of any organic solvent within 1-2 min.

Novel application of the palladium-catalyzed N-arylation of hydrazones to a versatile new synthesis of pyrazoles

A versatile synthesis of pyrazoles from aryl benzophenone hydrazones was demonstrated with a variety of 1,3-bifunctional substrates under acidic conditions. The obtained regioselectivity is consistent with transhydrazonation followed by subsequent cycliza