1016-41-7Relevant articles and documents
Scale-Up of a Continuous Manufacturing Process of Edaravone
He, Yan,Hong, Qingxia,Mei, Wenliu,Sun, Tiemin,Wu, Chengjun,Zhou, Shuhao
, p. 2146 - 2153 (2021)
Edaravone belongs to a class of brain-protective agents, which can scavenge free radicals. To reduce impurities and improve the yield, a continuous flow production process of edaravone was developed. The synthesis is continuously carried out in two steps. The throughput can reach 11.328 kg/day and the purity of the final product is 99.95%, which are in accordance with the needs of production. This is an efficient and quick production process suitable for industrial production.
ZnO: An Ecofriendly, Green Nano-catalyst for the Synthesis of Pyrazole Derivatives under Aqueous Media
Girish, Yarabally R.,Kumar, Kothanahally S. Sharath,Manasa, Heggadihalli S.,Shashikanth, Sheena
, p. 1175 - 1179 (2014)
An efficient nano ZnO catalyzed green protocol for the synthesis of pyrazol derivatives by condensation of different substituted phenyl hydrazines/semicarbazide/thiosemicarbazide with 1,3-diketone/ketoester at ambient temperature has been achieved. ZnO na
Room-temperature synthesis of pyrazoles, diazepines, β-enaminones, and β-enamino esters using silica-supported sulfuric acid as a reusable catalyst under solvent-free conditions
Chen, Xiang,She, Jin,Shang, Zhi-Cai,Wu, Jun,Zhang, Peizhi
experimental part, p. 947 - 957 (2009/09/06)
Silica-supported sulfuric acid (H2SO4·SiO2) has been utilized as a heterogeneous recyclable catalyst for a highly efficient regio- and chemoselective condensation of hydrazines/hydrazides, diamines, and primary amines with various β-dicarbonyl compounds at room temperature to afford pyrazoles, diazepines, and β-enaminones/β-enamino esters under solvent-free conditions within 5-15 min. Copyright Taylor & Francis Group, LLC.