10177-13-6Relevant articles and documents
Fast and efficient access to a family of multifunctional 1,3,5-trisubstituted piperidines
Diaz, Jose Luis,Fernandez-Forner, Dolors,Bach, Jordi,Lavilla, Rodolfo
, p. 2799 - 2813 (2008)
A collection of new 1,3,5-trisubstituted piperidines has been synthesized starting from the commercially available 5-bromonicotinic acid. A unified, diastereoselective strategy allows the controlled access to both cis and trans stereochemistries. The heterocyclic compounds thus prepared bear multiple functional groups suitable for structural diversification and combichem protocols. Copyright Taylor & Francis Group, LLC.
CASPASE 6 INHIBITORS AND USES THEREOF
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Paragraph 0400; 0440-0441, (2021/05/29)
Disclosed herein, inter alia, are compounds and methods for inhibiting Caspase 6 and the treatment of diseases. Provided is a method of treating a neurodegenerative disease, the method including administering to a subject in need thereof an effective amou
Synthesis of pinacol arylboronates from aromatic amines: A metal-free transformation
Qiu, Di,Jin, Liang,Zheng, Zhitong,Meng, He,Mo, Fanyang,Wang, Xi,Zhang, Yan,Wang, Jianbo
, p. 1923 - 1933 (2013/03/29)
A metal-free borylation process based on Sandmeyer-type transformation using arylamines derivatives as the substrates has been developed. Through optimization of the reaction conditions, this novel conversion can be successfully applied to a wide range of aromatic amines, affording borylation products in moderate to good yields. Various functionalized arylboronates, which are difficult to access by other methods, can be easily obtained with this metal-free transformation. Moreover, this transformation can be followed by Suzuki-Miyaura cross-coupling without purification of the borylation products, which enhances the practical usefulness of this method. A possible reaction mechanism involving radical species has been proposed.