102-61-4

Usage

Enzyme inhibitor

This trans-stilbene derivative (FW = 212.25 g/mol; CAS 102-61-4; M.P. = 155.5-156°C; low solubility in water), also known as (E) -3,5-stilbenediol and trans-3,5-dihydroxystilbene and named systematically as 5-[ (E) -2- phenylethenyl]benzene-1,3-diol, occurs naturally in the hardwood of pine and other woody plants. Pinosylvin exxhibits micromolar Ki values for specific isozymes of stilbene synthase and chalcone synthase. Target (s) : chalcone synthase; stilbene synthase; tyrosinase, or monophenol monooxygenase.

InChI:InChI=1/C15H14O2/c16-14-9-13(10-15(17)11-14)8-4-7-12-5-2-1-3-6-12/h1-7,9-11,16-17H,8H2/b7-4+

Upstream product

• 877-88-3 3,5-dimethoxybenzyl bromide 
• 100-52-7 benzaldehyde 
• 540-38-5 p-Iodophenol 
• 40243-87-6 3,5-dimethoxystyrene 
• 78916-49-1 1-phenyl-2-(3,5-dimethoxyphenyl)ethene 
• 7028-30-0 6-Styryl-β-resorcylsaeure 
• 100-39-0 benzyl bromide 

Downstream Products

• 26153-38-8 3,5-dihydroxybenzaldehyde 

Related news

pinosylvin (cas 102-61-4) reduced migration and invasion of oral cancer carcinoma by regulating matrix metalloproteinase-2 expression and extracellular signal-regulated kinase pathway08/03/2019

BackgroundPinosylvin possesses several biological properties, including anti-inflammatory, antitumor, and antioxidant characteristics. However, the effects of pinosylvin on the migration and invasion of human oral cancer cells and the underlying mechanisms remain unclear.detailed

Relevant academic research and scientific papers

PH-switched HRP-catalyzed dimerization of resveratrol: A selective biomimetic synthesis

A selective, concise and green biomimetic synthesis strategy of seven resveratrol dimers from natural resveratrol monomer as starting material is described. By succinct adjustment of environmental pH, the enzyme used, horseradish peroxidase (HRP), can perform in three distinctly different patterns and five dimers form with considerable selectivity. Two other derivative dimers are subsequently synthesized.

Pinosylvin-Based Polymers: Biodegradable Poly(Anhydride-Esters) for Extended Release of Antibacterial Pinosylvin

Pinosylvin is a natural stilbenoid known to exhibit antibacterial bioactivity against foodborne bacteria. In this work, pinosylvin is chemically incorporated into a poly(anhydride-ester) (PAE) backbone via melt-condensation polymerization, and characteriz

TRPA1 channels as targets for resveratrol and related stilbenoids

A series of twenty resveratrol analogues was synthesized and tested on TRPA1 and TRPV1 channels. None was able to significantly modulate TRPV1 channels. Conversely, most of them exhibited remarkably higher TRPA1 modulating activity than resveratrol. Optimal potency was observed with ortho monoxygenated stilbenes 6 and 17.