78916-49-1

Basic information

• Product Name: 3,5-DIMETHOXYSTILBENE
• Synonyms: dimethoxystilbene;AKOS 236-83;3,5-DIMETHOXYSTILBENE;PINOSYLVIN DIMETHYL ETHER;bianisal;bianisylidene;3,5-DIMETHOXYSTILBENE 98+%;(E)-1,3-dimethoxy-5-styrylbenzene
• CAS NO: 78916-49-1
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.3
• Product Categories: Stilbenes
• Mol File: 78916-49-1.mol
• Article Data: 11

Chemical Properties

• Melting Point: 56 °C
• Boiling Point: 376.5 °C at 760 mmHg
• Flash Point: 150.7 °C
• Appearance: /
• Density: 1.089 g/cm³
• Merck: 14,7451
• CAS DataBase Reference: 3,5-DIMETHOXYSTILBENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIMETHOXYSTILBENE(78916-49-1)
• EPA Substance Registry System: 3,5-DIMETHOXYSTILBENE(78916-49-1)

Safety Data

• Hazardous Substances Data: 78916-49-1(Hazardous Substances Data)

Usage

General Description

3,5-DIMETHOXYSTILBENE is a chemical compound known for its antioxidant properties and potential health benefits. It is a derivative of stilbene, a natural phenol found in plants, and is commonly used in research and pharmaceutical applications. Studies have shown that 3,5-DIMETHOXYSTILBENE has anti-inflammatory, anti-cancer, and neuroprotective effects, making it a promising candidate for the development of new drugs for various medical conditions. Additionally, it has been found to have potential applications in skincare products and as an ingredient in functional foods and dietary supplements due to its ability to neutralize free radicals and support overall health and wellness. Overall, 3,5-DIMETHOXYSTILBENE shows great potential for use in both medical and consumer products due to its numerous health-promoting properties.

Upstream product

• 877-88-3 3,5-dimethoxybenzyl bromide 
• 100-52-7 benzaldehyde 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 100-39-0 benzyl bromide 
• 540-38-5 p-Iodophenol 
• 40243-87-6 3,5-dimethoxystyrene 
• 108957-75-1 diethyl 3,5-dimethoxybenzylphosphonate 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 100-53-8 phenylmethanethiol 
• 27691-43-6 1-(benzylsulphanyl)-4-Nitrobenzene 
• 42497-88-1 4-(4-nitrophenylsulfonylmethyl)benzene 
• 16721-45-2 triphenyl(phenylmethylene)phosphorane 
• 1100-88-5 benzyltriphenylphosphonium chloride 

Downstream Products

• 102-61-4 3,5-dihydroxystilbene 
• 5150-38-9 3-Hydroxy-5-methoxystilbene 
• 22139-77-1 pinosylvin 
• 78916-46-8 2,2-dimethyl-7-methoxy-5-(2-phenylethyl)chroman 
• 78916-45-7 2,2-dimethyl-7-hydroxy-5-(2-phenylethyl) chroman 
• 14531-52-3 dihydropinosylvin 
• 205931-01-7 diethyl-carbamic acid 2-allyl-3-(2-methyl-allyloxy)-5-phenethyl-phenyl ester 
• 205931-17-5 diethyl-carbamic acid 3-methyl-8-phenethyl-2,5-dihydro-benzo[b]oxepin-6-yl ester 
• 205931-00-6 diethyl-carbamic acid 2-allyl-3-methoxy-5-phenethyl-phenyl ester 
• 205931-15-3 2-Allyl-1-methoxy-3-(2-methyl-allyloxy)-5-phenethyl-benzene 
• 205933-00-2 2-Allyl-1-methoxy-3-methoxymethoxy-5-phenethyl-benzene 
• 205930-99-0 diethyl-carbamic acid 3-methoxy-5-phenethyl-phenyl ester 

Relevant articles and documents

Two resveratrol analogs, pinosylvin and 4,4′-dihydroxystilbene, improve oligoasthenospermia in a mouse model by attenuating oxidative stress via the Nrf2-ARE pathway

Two synthesized resveratrol analogs from our laboratory, namely pinosylvin (3,5-dihydroxy-trans-stilbene, PIN) and 4,4′-dihydroxystilbene (DHS), have been carefully evaluated for treatment of oligoasthenospermia. Recent studies have demonstrated that PIN and DHS improved sperm quality in the mouse. However, the mechanism of action of PIN and DHS on oligoasthenospermia remains unknown. Herein, we investigated the mechanistic basis for improvements in sperm parameters by PIN and DHS in a mouse model of oligoasthenospermia induced by treatment with busulfan (BUS) at 6 mg/kg b.w. Two weeks following busulfan treatment, mice were administered different concentrations of PIN or DHS daily for 2 consecutive weeks. Thereafter, epididymal sperm concentration and motility were determined, and histopathology of the testes was performed. Serum hormone levels including testosterone (T), luteinizing hormone (LH), and follicle stimulating hormone (FSH) were measured using corresponding specific enzyme-linked immunosorbent assay (ELISA) kits. Testicular mRNA expression profiles were determined by RNA sequencing analysis. These findings were validated by quantitative real-time PCR, western blotting and ELISA. Both PIN and DHS improved the epididymal sperm concentration and motility, enhanced testosterone levels, and promoted testicular morphological recovery following BUS treatment. PIN treatment was found to significantly reduce oxidative stress via the nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE)-dependent antioxidant, glutathione peroxidase 3. DHS treatment significantly reduced oxidative stress via the Nrf2-ARE-dependent antioxidants glutathione S-transferase theta 2 and glutathione S-transferase omega 2. In summary, PIN and DHS ameliorated oligoasthenospermia in this mouse model by attenuating oxidative stress via the Nrf2-ARE pathway.

Method for synthesizing olefin compound by photo-induced one-pot process

The invention discloses a method for synthesizing an olefin compound by a photo-induced one-pot process. The method comprises the following step of subjecting a halohydrocarbon and an aldehyde compound to a reaction under the condition of irradiation in an inert atmosphere by taking alkali metal carbonate as a base, taking an organic phosphine compound as an adjuvant and taking a photosensitizer as a catalyst, thereby obtaining the olefin compound. According to the method disclosed by the invention, the olefin compound is produced from the halohydrocarbon and the aldehyde compound in a high-yield manner under the condition of irradiation in the inert atmosphere under normal-temperature reaction conditions by taking acetonitrile, DMF (N,N-dimethylformamide) or DMA (N,N-dimethylacetamide) asa solvent, taking an organic phosphine reagent as a reaction adjuvant, taking the alkali metal carbonate as the base and taking the photosensitizer as the catalyst. Compared with the conventional olefin synthesis methods, the method disclosed by the invention has the obvious advantages that the reaction raw materials are readily available, the tolerance to a variety of functional groups on halohydrocarbons and aldehydes is high, the yield is high, the separation and purification of a product are simple and convenient, and the like.

Pinosylvin-Based Polymers: Biodegradable Poly(Anhydride-Esters) for Extended Release of Antibacterial Pinosylvin

Pinosylvin is a natural stilbenoid known to exhibit antibacterial bioactivity against foodborne bacteria. In this work, pinosylvin is chemically incorporated into a poly(anhydride-ester) (PAE) backbone via melt-condensation polymerization, and characteriz