102423-74-5Relevant academic research and scientific papers
Multicomponent Synthesis of 4-Alkyl(Aryl, Hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)- 3,6-diamino-5-cyanothieno[2,3-b]pyridines
Dyachenko,Dyachenko,Dorovatovskii,Khrustalev,Nenajdenko
, p. 1435 - 1445 (2019/01/04)
The condensation of malononitrile with hydrogen sulfide and aldehydes in the presence of triethylamine in ethanol at room temperature afforded 4-alkyl(aryl, hetaryl)-2,6-diamino-3,5-dicyano-4H-thiopyrans. Treatment of the latter in situ with alkali in DMF, followed by addition of an alkylating agent, led to the formation of 4-alkyl(aryl, hetaryl)-2-alkoxycarbonyl(aroyl, carbamoyl)-3,6-diamino-5-cyanothieno[2,3-b]- pyridines.
Bis(4-pyridylamino)triazine-stabilized magnetite nanoparticles: preparation, characterization and application as a retrievable catalyst for the green synthesis of 4H-pyran, 4H-thiopyran and 1,4-dihydropyridine derivatives
Bodaghifard,Mobinikhaledi,Asadbegi
, (2017/02/05)
Synthesis of bis(4-pyridylamino)triazine stabilized on silica-coated nano-Fe3O4 particles, and their feasibility as a reusable heterogeneous basic catalyst are reported. The catalytic performance of this novel material was studied fo
ACETYL-COA CARBOXYLASE MODULATORS
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Paragraph 00266-00270, (2015/01/09)
Provided herein are compounds that exhibit activity as acetyl-CoA carboxylase modulators (e.g., inhibitors) and are useful, for example, in methods for the control of fungal pathogens in plants.
CYCLIZATION OF NITRILES. XXXIII. SYNTHESIS AND STRUCTURE OF 4-ARYL-2,6-DIAMINO-3,5-DICYANOTHIOPYRANS AND THEIR RECYCLIZATION TO 6-AMINO-4-ARYL-3,5-DICYANO-2(1H)-PYRIDINETHIONES
Sharanin, Yu. A.,Shestopalov, A. M.,Nesterov, V. N.,Melenchuk, S. N.,Promonenkov, V. K.,et al.
, p. 1189 - 1196 (2007/10/02)
Like the three-component condensation of aromatic aldehydes, malononitrile, and cyanothioacetamide, the reaction of arylidenemalononitriles with cyanothioacetamide and of arylidenecyanothioacetamides with malononitrile leads to the formation of 4-aryl-2,6-diamino-3,5-dicyano-4H-thiopyrans.It was established by x-ray crystallographic investigation that the 4H-thiopyran ring in the obtained compounds has the boat conformation.Under the influence of bases the 4H-thiopyrans readily undergo recyclization to 6-amino-4-aryl-3,5-dicyano-2(1H)-pyridinethiones.
Activated Nitriles in Heterocyclic Synthesis: The Reaction of Cyanothioacetamide with Activated Double Bond Systems
Galil, Fathy Mohamed Abdel,Sallam, Mohamed Mohamed,Sherif, Sherif Mourad,Elnagdi, Mohamed Hilmy
, p. 1639 - 1644 (2007/10/02)
Die Reaktion von Benzylidenmalononitrilen mit Cyanthioacetamid (1) ergibt je nach den Reaktionsbedingungen entweder Thiopyrane oder Pyridine.Die Strukturen der Reaktionsprodukte wurden mittels 13C-NMR aufgeklaert.
Nitriles in Heterocyclic Synthesis: Novel Synthesis of 4H-Thiopyran and of 2-Hydroxy-6-pyridine Thione Derivatives
Elgemeie, Galal Eldin Hamza,Sherif, Sherif Mourad,Aal, Fatma Abd El Maksoud Abd El,Elnagdi, Mohamed Hilmy
, p. 781 - 783 (2007/10/02)
Reaction of arylmethylenemalononitrile 2a-c with cyanothioacetamide 1 afforded 4-aryl-2,6-diamino-4H-thiopyran-3,5-dicarbonitriles 5a-c on refluxing in ethanolic aqueous triethylamine, rearranged to yield the 4-aryl-1,2-dihydro-6-hydroxy-2-thioxo-3,5-pyridine dicarbonitriles 8a-c.The same compounds could be obtained on treatment of 2a-c with 1 in ethanolic aqueous triethylamine or on reacting 1 with 2d-f.The 13C NMR data of the products are reported and interpreted. - Keywords: Cyanothioacetamide, 2-Aminothiopyranes, Pyridine Thiones, 13C NMR Spectra
A NOVEL SYNTHESIS OF 4-H-THIOPYRANS : UNEXPECTED PRODUCTS OF REACTION OF CYANOTHIOACETAMIDE WITH CINNAMONITRILE DERIVATIVES
Elgemeie, Galal Eldin Hamza,Sallam, Mohamed Mohamed Mohamed,Sherif, Sherif Mourad,Elnagdi, Mohamed Hilmy
, p. 3107 - 3110 (2007/10/02)
The reaction of arylidenemalononitrile with cynothioacetamide afforded either thiopyrans or pyridine derivatives depending on reaction conditions. 13 C NMR was utilised to elucidate the proposed structures of the reaction products.
