10287-54-4

Basic information

• Product Name: ETHYL 4-(N,N-DIETHYLAMINO)BENZOATE
• Synonyms: ETHYL P-DIETHYLAMINOBENZOATE;ETHYL 4-(N,N-DIETHYLAMINO)BENZOATE;P-DIETHYLAMINOBENZOIC ACID ETHYL ESTER;RARECHEM AL BI 0080;TIMTEC-BB SBB009978;ethyl 4-diethylaminobenzoate;4-Diethylaminobenzoic acid ethyl ester;p-Diethylaminoethylbenzoate
• CAS NO: 10287-54-4
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.3
• EINECS: 233-635-9
• Product Categories: Aromatic Esters
• Mol File: 10287-54-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 39-43°C
• Boiling Point: 362.36°C (rough estimate)
• Flash Point: 119°C
• Appearance: /
• Density: 1.0451 (rough estimate)
• Vapor Pressure: 0.000194mmHg at 25°C
• Refractive Index: 1.5175 (estimate)
• PKA: 4.13±0.32(Predicted)
• CAS DataBase Reference: ETHYL 4-(N,N-DIETHYLAMINO)BENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-(N,N-DIETHYLAMINO)BENZOATE(10287-54-4)
• EPA Substance Registry System: ETHYL 4-(N,N-DIETHYLAMINO)BENZOATE(10287-54-4)

Safety Data

• Hazardous Substances Data: 10287-54-4(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(N,N-diethylamino)benzoate, also known as Benzocaine, is a local anesthetic commonly used in over-the-counter products such as throat lozenges, ear drops, and topical pain relievers. It works by numbing the area of application, providing temporary relief from pain and discomfort. Benzocaine is an ester, meaning it is a compound formed from an alcohol and an acid, and is often used in the formulation of various medication and personal care products. However, it is important to note that excessive use of products containing benzocaine can lead to side effects such as allergic reactions, skin irritation, and in rare cases, methemoglobinemia. Therefore, it is advised to use benzocaine-containing products as directed and to seek medical attention if any adverse reactions occur.

InChI:InChI=1/C13H19NO2/c1-4-14(5-2)12-9-7-11(8-10-12)13(15)16-6-3/h7-10H,4-6H2,1-3H3

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 75-03-6 ethyl iodide 
• 50-00-0 formaldehyd 
• 94-09-7 p-aminoethylbenzoate 
• 122-52-1 triethyl phosphite 
• 64-17-5 ethanol 
• 99-77-4 ethyl 4-nitrobenzoate 
• 762-04-9 phosphonic acid diethyl ester 
• 5429-28-7 4-(diethylamino)benzoic acid 

Downstream Products

• 7449-27-6 N-ethyl-2,4,6-trinitroaniline 
• 91182-00-2 ethyl 4-(ethylamino)-3-nitrobenzoate 
• 861601-78-7 4-(ethyl-nitro-amino)-3,5-dinitro-benzoic acid ethyl ester 
• 861601-64-1 4-(ethyl-nitroso-amino)-3,5-dinitro-benzoic acid ethyl ester 

Relevant articles and documents

A strategy of two-step tandem catalysis towards direct N-alkylation of nitroarenes with ethanol via facile fabricated novel Co-based catalysts derived from coordination polymers

Three novel N-doped carbon supported Co/Co3O4 catalysts, namely, Co@CN-hmta, Co@CN-larg and Co-Co3O4@CN-bipy, with sheet-, worm-, honeycomb-like morphologies respectively, have been fabricated by the pyrolysis of well-defined coordination polymers (CPs). Upon the as-prepared catalysts were applied for the reaction of N-alkylation of nitroarenes with ethanol, a direct two-step tandem reaction is realized, in which the Co@CN-hmta delivers 100% conversion/selectivity of N-ethylaniline/N,N-diethylaniline from the direct N-alkylation of nitroarenes with ethanol. The kinetic studies were conducted to confirm that the N-alkylation of aniline with ethanol is the rate-determining step in the two-step tandem reaction. The SEM/EDX, XRD, Raman, TEM, XPS, and CO2-TPD characterization results have revealed that sizes and dispersion of metallic Co, amount of structural defects and surface Lewis basicity towards three catalysts can be tuned by changing the structures of Co-based CPs designed by different organic linkers, which may also help to understand the preparation of industrial catalysts on a molecular level. The optimized Co@CN-hmta catalyst is easily recycled by using the external magnet for successive reuses without any loss in both activity and selectivity. To the best of our knowledge, this is the first carbon-nitrogen species supported Co/Co3O4 catalysts derived from the CPs, which could effectively catalyzed the N-alkylation of nitroarenes with ethanol to produce the secondary amines and/or tertiary amines. This low-cost, recyclable and easy scale-up N-doped carbon supported catalyst may be of potential application in various heterogeneous catalytic reactions.

PHOSPHONOMETHYLATION OF ANESTHESIN AND RADIOPROTECTANT ACTIVITY OF THE PRODUCTS

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