2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE

Base Information

• Chemical Name: 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE
• CAS No.: 1029-52-3
• Molecular Formula: C14H16N4O
• Molecular Weight: 256.307
• Hs Code.: 2933990090
• Mol file: 1029-52-3.mol

Synonyms:2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE;2-AMino-6-benzyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyriMidin-4-one

Chemical Property of 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE

Chemical Property:

• PSA: 75.01000
• LogP: 1.42950

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Amino-6-benzyl-5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE

There total 5 articles about 2-AMINO-5,6,7,8-TETRAHYDRO-6-(PHENYLMETHYL)PYRIDO[4,3-D]PYRIMIDIN-4(3H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C9H14O3NC6H5 (41276-30-6) + guanidine nitrate (113-00-8) → 2-amino-6-benzyl-5,6,7,8-tetrahydropyrido[4.3-d]pyrimidin-4-ol (1029-52-3)

Guidance literature:

With ethanol; sodium; for 16h; Heating;

DOI:10.1016/j.tet.2007.07.100

Reference yield: 87.0%

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester (57611-47-9) + guanidine hydrochloride (50-01-1) → 2-amino-6-benzyl-5,6,7,8-tetrahydropyrido<4,3-d>pyrimidin-4(3H)-one (1029-52-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide;

Reference yield:

guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) + ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride (1454-53-1) → 2-amino-6-benzyl-5,6,7,8-tetrahydropyrido[4.3-d]pyrimidin-4-ol (1029-52-3)

Guidance literature:

In ethanol; at 120 ℃; for 16h;

upstream raw materials:

C₉H₁₄O₃NC₆H₅

guanidine nitrate

guanidine hydrogen carbonate

ethyl 1-benzyl-4-oxopiperidine-3-carboxylate hydrochloride

Downstream raw materials:

tert-butyl (6-benzyl-4-((tert-butoxycarbonyl)(butyl)amino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-yl)(tert-butoxycarbonyl)carbamate

6-benzyl-N⁴-butyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-2,4-diamine

6-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-2-amine

(S)-2-{4-[2-(2-Amino-4-oxo-3,5,7,8-tetrahydro-4H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid dimethyl ester