10310-60-8Relevant academic research and scientific papers
The Synthesis of N-Substituted Ureas I: The N-Alkylation of Ureas
Hackl, Kurt A.,Falk, Heinz
, p. 599 - 606 (1992)
Urea and N-alkylureas are N'-alkylated in low yields using aprotic dipolar solvents, like dimethylsulfoxide, solid potassium hydroxide, and alkyl halides.Phase transfer catalysis with tetrabutylammonium chloride in refluxing toluene results in high yield
Synthesis and application of a new fluorous-tagged ammonia equivalent
Nielsen, Simon D.,Smith, Garrick,Begtrup, Mikael,Kristensen, Jesper L.
supporting information; experimental part, p. 4557 - 4566 (2010/08/20)
A novel fluorous-tagged ammonia equivalent has been developed. It is based on a nitrogen-oxygen bond, which can be cleaved in a traceless manner by a molybdenum complex or samarium diiodide. The application in the synthesis of ureas, amides, sulfonamides, and carbamates is described. The scope of the fluo-rous N-O linker is exemplified by the synthesis of itopride, a drug used for the treatment of functional dyspepsia. Itopride was synthesized with the aid of fluorous purification methods and the product was isolated in good overall yield, with high purity.
Trapping! of isocyanates with benzotriazole in situ - Preparation of carbamoyl benzotriazoles as an isocyanate alternative via curtius rearrangement
Zhong, Zhiyun,Wang, Xiaoxia,Kong, Lichun,Zhu, Xiangming
experimental part, p. 2461 - 2464 (2010/01/07)
N-Aryl and N-alkenyl carbamoyl benzotriazoles were prepared in good to excellent yields from acyl azides and benzotriazole via Curtius rearrangement, while N-alkylcarbamoyl benzotriazoles were formed from N-alkanoyl benzotriazoles and sodium azide in one
Process for the N-alkylation or ureas
-
, (2008/06/13)
Process for the N-alkylation of ureas by reacting a urea with an alkylating agent in the presence of a solid base and a phase transfer catalyst in a diluent.
