10386-93-3

Basic information

• Product Name: N-cyclohexyl-4-methylaniline
• Synonyms: N-cyclohexyl-4-methylaniline
• CAS NO: 10386-93-3
• Molecular Formula: C₁₃H₁₉N
• Molecular Weight: 189.29666
• Mol File: 10386-93-3.mol
• Article Data: 55

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-cyclohexyl-4-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-cyclohexyl-4-methylaniline(10386-93-3)
• EPA Substance Registry System: N-cyclohexyl-4-methylaniline(10386-93-3)

Safety Data

• Hazardous Substances Data: 10386-93-3(Hazardous Substances Data)

Usage

General Description

N-cyclohexyl-4-methylaniline is a chemical compound with the molecular formula C13H19N. It is a substituted aniline, containing a cyclohexyl group and a methyl group attached to the amino group. N-cyclohexyl-4-methylaniline is commonly used as an intermediate in the synthesis of dyes, pigments, and pharmaceuticals. It is also utilized as a corrosion inhibitor in the oil and gas industry. N-cyclohexyl-4-methylaniline is a clear to slightly yellow liquid with a mild aromatic odor. It is considered to be hazardous if ingested, inhaled, or in contact with skin, and precautions should be taken when handling this compound.

Upstream product

• 108-94-1 cyclohexanone 
• 106-49-0 p-toluidine 
• 540-23-8 p-toluidine hydrochloride 
• 110-83-8 cyclohexene 
• 108-93-0 cyclohexanol 
• 29540-83-8 p-tolyl triflate 
• 108-91-8 cyclohexylamine 
• 150-19-6 O-methylresorcine 
• 108-85-0 1-bromocyclohexane 
• 106-44-5 p-cresol 
• 98-89-5 Cyclohexanecarboxylic acid 
• 17797-15-8 1-(p-Tolyl)-cyclohexylamin 
• 99-99-0 1-methyl-4-nitrobenzene 
• 106-48-9 4-chloro-phenol 

Downstream Products

• 87261-67-4 2-[(N-cyclohexyl-4-methylanilino)methyl]-4,5-dihydro-1H-imidazole 
• 865288-85-3 N-cyclohexyl-2-iodo-4-methylaniline 
• 1451061-04-3 1-cyclohexyl-5-methylindoline-2,3-dione 

Relevant articles and documents

Efficient protocol for reductive amination of aldehydes and ketones with sodium borohydride in an ionic liquid/H2O system

The imines were generated in situ from carbonyl compounds and amines, which undergo smooth reduction with sodium borohydride in an ionic liquid/H 2O solvent system. The reaction conditions were very mild and neutral to afford the corresponding highly functionalized amines in excellent yields. Copyright Taylor & Francis Group, LLC.

Reaction of trialkylborane. II. The reaction of trialkylborane with aromatic nitro compounds (author's transl)

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Buchwald-Hartwig amination using Pd(i) dimer precatalysts supported by biaryl phosphine ligands

We report the synthesis of air-stable Pd(i) dimer complexes featuring biaryl phosphine ligands. Catalytic experiments suggest that these complexes are competent precatalysts that can mediate cross-coupling amination reactions between aryl halides with bot

A new efficient palladium catalyst for the amination of aryl chlorides

A highly active catalyst for the Buchwald-Hartwig amination has been developed. The new catalyst, a combination of a dimethylaminomethyl ferrocene palladacycle and bis(2-nor-bornyl)phosphine shows high activity and broad scope for the coupling of non- or deactivated aryl chlorides with primary and secondary amines as well as (hindered) anilines.

Porous polymeric ligand promoted copper-catalyzed C-N coupling of (hetero)aryl chlorides under visible-light irradiation

A porous polymeric ligand (PPL) has been synthesized and complexed with copper to generate a heterogeneous catalyst (Cu@PPL) that has facilitated the efficient C-N coupling with various (hetero)aryl chlorides under mild conditions of visible-light irradiation at 80 °C (58 examples, up to 99% yields). This method could be applied to both aqueous ammonia and substituted amines, and is compatible to a variety of functional groups and heterocycles, as well as allows tandem C-N couplings with conjunctive dihalides. Furthermore, the heterogeneous characteristic of Cu@PPL has enabled a straightforward catalyst separation in multiple times of recycling with negligible catalytic efficiency loss by simple filtration, affording reaction mixtures containing less than 1 ppm of Cu residue. [Figure not available: see fulltext.]

Band-Gap Narrowing of Highly Stable Heterogeneous ZrO2–ZnO Nanocomposites for the Reductive Amination of Carbonyl Compounds with Formic Acid and Triethylamine

The band gap of a material can be affected by factors such as size, doping materials, and oxygen vacancies. The decrease in band gap and change in state of ZrO2 with the addition of ZnO indicates interfacial interactions between ZrO2 and ZnO in the nanocomposites (NCs), which is further confirmed by the observed shift of the peaks in the Raman spectra. Heterobimetallic ZrO2–ZnO NCs were synthesized through a sustainable green approach by using sucrose isolated from Angelica gigas Nakai root extract. The highly stable NCs displayed excellent catalytic activity for reductive amination of carbonyl compounds utilizing HCO2H/(CH3CH2)3N as a hydrogen source. The high catalytic performance of the NCs was closely correlated with the narrow band gap and synergistic effect of ZrO2 with ZnO in the NCs.