10399-10-7

Upstream product

• 14062-24-9 4-chloro-benzeneacetic acid, ethyl ester 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 124-41-4 sodium methylate 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 99-91-2 para-chloroacetophenone 
• 149-73-5 trimethyl orthoformate 
• 67-56-1 methanol 
• 7138-34-3 p-chloromandelic acid 
• 32174-34-8 methyl 4-chloromandelate 
• 74-88-4 methyl iodide 
• 104-88-1 4-chlorobenzaldehyde 
• 58058-79-0 1-Chloro-4-((E)-2-methanesulfonyl-2-methylsulfanyl-vinyl)-benzene 
• 83831-71-4 1-Chloro-4-((E)-2-methanesulfinyl-2-methanesulfonyl-vinyl)-benzene 

Downstream Products

• 4674-24-2 2-(4-chlorophenyl)-2-methoxyacetic acid 
• 37542-28-2 methyl (p-chlorphenyl)glyoxylate 

Relevant academic research and scientific papers

SERINE/THREONINE KINASE INHIBITORS

Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

Hypervalent iodine oxidation of trimethylsilyl ketene acetals: A convenient route to α-methoxylation of esters and lactones

Hypervalent iodine oxidation of trimethylsilyl ketene acetals of esters and lactones using iodosobenzene in methanol affords the corresponding α- methoxylated carbonyl compounds in good yields.

Electrochemical methoxylation of arylacetates

Electrochemical methoxylation at the active methylene group of phenylacetates and 1-naphthaleneacetate was conducted successfully at room temperature, in methanol containing potassium iodide as an electron carrier and sodium methoxide as a base and a methoxylating agent. Along with the mono-methoxylated products, dimethoxy, hydroxy, and oxo derivatives as well as the dimers (succinates) were produced as by-products.

Hypervalent Iodine Oxidation of Aryl Methyl Ketones: A Convenient Route to Methyl α-Methoxyarylacetates

Hypervalent iodine oxidation of aryl methyl ketones using two equivalents of iodosobenzene diacetate leads to 1,2-aryl migration followed by solvohyperiodination to yield the corresponding methyl α-methoxyarylacetates.

HYPERVALENT IODINE IN ORGANIC SYNTHESIS. A NEW ROUTE TO α-FUNCTIONALIZED CARBOXYLATE ESTERS.

Aryl and alkylcarboxylate esters are converted into the corresponding α-hydroxy acids or α-alkoxyesters upon treatment with C6H5I(OAc)2 and base in the appropriate solvent.