A new high yield semisynthetic approach to (20S)-9-NH2-Camptothecin based on a sequence of palladium-catalysed reductions

DOI: 10.1016/0040-4039(95)01939-F

Source and publish data:

Tetrahedron Letters p. 9197 - 9200 (1995)

Update date:2022-08-12

Topics:

Authors:

Cabri, Walter

Candiani, Ilaria

Zarini, Franco

Penco, Sergio

Bedeschi, Angelo

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Article abstract of DOI:10.1016/0040-4039(95)01939-F

A new 5-step synthesis of 9-NH₂-Camptothecin starting from natural Camptothecin is described. The approach, centred on a double palladium catalysed reduction of an arylsulfonate and a nitro group, has an overall yield consistently higher than the previously reported ones.

Full text of DOI:10.1016/0040-4039(95)01939-F

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