104386-86-9Relevant academic research and scientific papers
Palladium-Catalyzed One-Pot Four-Component Synthesis of β-Cyano-α,β-unsaturated Ketones Using Calcium Carbide as an Acetylene Source and Potassium Hexacyanoferrate(II) as an Eco-Friendly Cyanide Source
Lu, Hao,Li, Zheng
, p. 4474 - 4482 (2019/08/20)
Palladium-catalyzed one-pot four-component synthesis of β-cyano-α,β-unsaturated ketones by the reactions of aryl halides, calcium carbide, potassium hexacyanoferrate(II) and aroyl chlorides is described. The salient features of this protocol are the direct use of easy-to-handle acetylene source and eco-friendly cyanide source, wide scope of substrates with good functional group tolerance, and simple work-up procedure. (Figure presented.).
New preparation of (Z)-1-phenyl-3-cyano-2-propen-1-ones
Trabulsi, Houssam,Rousseau, Gerard
experimental part, p. 2123 - 2134 (2011/07/09)
Reaction of γ-phenyl-β,γ-unsaturated hydroxamates with bis(collidine)-bromine(I) hexafluorophosphate led to the formation of cyclic bromo imidates. Reaction of these with triethylamine led to the formation of 3-cyano-2-propen-1-ones with good yields by a
Ni(0)-catalyzed conjugate addition of Me3SiCN to Ynones: α-bromo-β-cyano tetrasubstituted enones
Arai, Takayoshi,Suemitsu, Yuuki,Ikematsu, Yui
supporting information; experimental part, p. 333 - 335 (2009/07/04)
(Chemical Equation Presented) Conjugate addition of Me3SiCN to ynones is smoothly catalyzed by Ni(cod)2 to give the β-cyanosilyloxyallene quantitatively. Further reaction of the silyloxyallenes with NBS provides the tetrasubstituted
Copper-catalyzed addition reactions of aromatics and ketones to 2-aza-2,4-cyclopentadienone: Facile and efficient transformation of carbonyl-ene-nitriles to 1H-pyrrolin-2(5H)-ones
Murai, Masahito,Miki, Koji,Ohe, Kouichi
supporting information; experimental part, p. 9174 - 9176 (2009/04/06)
(Chemical Equation Presented) Copper-catalyzed reactions of carbonyl-ene-nitriles with carbon nucleophiles, such as aromatics and ketones, afforded pyrrolin-2-ones (γ-lactam) in excellent yield. The reaction mechanism involves addition reactions with a ke
Palladium-Catalyzed Acylcyanation of Terminal Arylacetylenes. Synthesis of 1,3-Diaryl-3-cyano-2-propen-1-ones and Tetrasubstituted Furans
Nozaki, Kyoko,Sato, Naomasa,Takaya, Hidemasa
, p. 1629 - 1637 (2007/10/03)
(Z)-1,3-Diaryl-3-cyano-2-propen-1-ones ((Z)-1) are prepared from arenecarbonyl cyanide and terminal arylacetylene in the presence of Pd(OAc)2-PPh3 (1 mol amt. to Pd)-0.5dppb (1,4-bis(diphenylphosphino)butane) (0.5 mol amt. to Pd). The reaction proceeded via the formation of acetylenic ketone 3, followed by the palladium-catalyzed addition of HCN, and isomerization of the resulting (E)-1 to (Z)-1. Oxidative addition of arenecarbonyl cyanide to zero-valent palladium metal has been observed by admixture of 4-MeOC6H4COCN to Pd2(dba)3 · CHCl3-PPh3-0.5dppb oxide (dppb oxide = Ph2P(O)(CH2)4P(O)Ph2). The resulting Pd(4-MeOC6H4CO)(CN)(PPh3)(ligand) afforded (Z)-1c by reaction with phenylacetylene. Thus, the role of two kinds of phosphine, PPh3 and dppb, suggests that the former acts as a ligand and the latter works as a reductant of Pd(II). The product (Z)-1 can be photoisomerized to (E)-1 under room light in CDCl3. The product (Z)-1 was obtained by a four-component coupling reaction of 4-iodotoluene, phenylacetylene, KCN, and carbon monoxide. A new synthesis of tetrasubstituted furans is also mentioned.
Acylcyanation of Terminal Acetylenes: Palladium-Catalyzed Addition of Aryloyl Cyanides to Arylacetylenes
Nozaki, Kyoko,Sato, Naomasa,Takaya, Hidemasa
, p. 2679 - 2681 (2007/10/02)
Two different electron-withdrawing carbon substituents (aryloyl group and nitrile group) were introduced into terminal arylacetylenes by a new method, palladium-catalyzed intermolecular acylcyanation of the acetylenic bonds.
