104531-92-2

Upstream product

• 98-89-5 Cyclohexanecarboxylic acid 
• 673-32-5 1-Phenylprop-1-yne 
• 126812-30-4 1,3-dioxoisoindolin-2-yl cyclohexanecarboxylate 
• 626-62-0 Cyclohexyl iodide 
• 140226-79-5 2-Cyclohexyl-1-phenyl-prop-2-en-1-ol 
• 83477-69-4 1-acetylcyclohexane-2,4,6-triisopropylbenzenesulfonyl hydrazone 
• 140226-86-4 Dithiocarbonic acid S-((Z)-2-cyclohexyl-3-phenyl-allyl) ester S-methyl ester 

Relevant academic research and scientific papers

Ni-Catalyzed deaminative hydroalkylation of internal alkynes

A regioselective cis-hydroalkylation of internal alkynes with readily prepared Katritzky pyridinium salts for the synthesis of tri-substituted alkenes is described. This reaction is the first example of a metal-catalyzed hydroalkylation of an alkyne via C-N bond activation of an amine. The reaction demonstrates broad scope and functional group tolerance, allowing access to desired products with high diversity. Preliminary mechanistic studies indicate that a combination of an SET-initiated radical process and Ni-catalyzed alkylation could engage in the reaction, which makes it possible to bypass the traditional open-shell addition pathway.

Synthesis of trisubstituted olefins via nickel-catalyzed decarboxylative hydroalkylation of internal alkynes

A novel NiH-catalyzed decarboxylative hydroalkylation of internal alkynes has been developed. Trisubstituted olefins were obtained in moderate to good yields with good regioselectivities. The reaction involves cis addition of NiH to the internal alkyne. The reaction shows good functional-group tolerance.

A Convergent Method for the Stereoselective Synthesis of Trisubstituted Alkenes

A method for the stereoselective, convergent synthesis of trisubstituted alkenes has been developed.The procedure features the synthesis of allylic alcohols 9 by coupling an aldehyde with a vinyl organometallic reagent.Treatment of 9 with carbon disulfide