104723-32-2Relevant academic research and scientific papers
SYNTHESIS OF SINGLE ISOMERS (E OR Z) OF PROTECTED γ,δ-UNSATURATED KETONES BY THE HORNER-WITTIG REACTION
Cornish Christopher A.,Warren, Stuart
, p. 2585 - 2598 (2007/10/02)
The lithium derivative of the γ-diphenylphosphinoyl ketal (10a) added to aldehydes and ketones to give stable Horner-Wittig intermediates (11) which were separated and converted into single isomers (E or Z) or γ,δ-unsaturated ketals (12). erythro-Adducts (11) and hence Z-(12), were selectively formed by addition of aldehydes and threo adducts (11), and hence E-(12), by reduction of the corresponding α-diphenylphosphinoyl ketones (13), prepared by acylation of the same γ-diphenylphosphinoyl ketal (10a).
