104886-22-8Relevant academic research and scientific papers
Nickel-catalyzed removal of alkene protecting group of phenols, alcohols via chain walking process
Meng, Chenkai,Niu, Haolin,Ning, Juehan,Wu, Wengang,Yi, Jun
supporting information, (2020/02/04)
An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group.
Palladium-catalyzed carbonylative cyclization of aryl alkenes/alkenols: A new reaction mode for the synthesis of electron-rich chromanes
Li, Shuang,Li, Fuzhuo,Gong, Jianxian,Yang, Zhen
supporting information, p. 1240 - 1243 (2015/03/14)
The Pd(II)-catalyzed intramolecular carbonylative cyclization reaction of aryl alkenes and aryl alkenols is reported for the synthesis of structurally diverse chromanes. PdCl2(CH3CN)2 was used as the catalyst and CuCl2 as the oxidant under the balloon pressure of CO. The reaction is conducted under mild conditions, and chromane-type esters and lactones can be generated in a highly regio- and stereoselective manner.
COMPOUNDS AND METHODS FOR TREATING AIDS AND HIV INFECTIONS
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Page/Page column 33, (2010/12/17)
Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described.
Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance
Ghosh, Arun K.,Kulkarni, Sarang,Anderson, David D.,Hong, Lin,Baldridge, Abigail,Wang, Yuan-Fang,Chumanevich, Alexander A.,Kovalevsky, Andrey Y.,Tojo, Yasushi,Amano, Masayuki,Koh, Yasuhiro,Tang, Jordan,Weber, Irene T.,Mitsuya, Hiroaki
experimental part, p. 7689 - 7705 (2010/05/19)
The structure-based design, synthesis, and biological evaluation of a series of nonpeptidic macrocyclic HIV protease inhibitors are described. The inhibitors are designed to effectively fill in the hydrophobic pocket in the S1′ - S2′ subsites and retain all major hydrogen bonding interactions with the protein backbone similar to darunavir (1) or inhibitor 2. The ring size, the effect of methyl substitution, and unsaturation within the macrocyclic ring structure were assessed. In general, cyclic inhibitors were significantly more potent than their acyclic homologues, saturated rings were less active than their unsaturated analogues and a preference for 10- and 13-membered macrocylic rings was revealed. The addition of methyl substituents resulted in a reduction of potency. Both inhibitors 14b and 14c exhibited marked enzyme inhibitory and antiviral activity, and they exerted potent activity against multidrug-resistant HIV-1 variants. Protein - ligand X-ray structures of inhibitors 2 and 14c provided critical molecular insights into the ligand-binding site interactions.
Facile construction of the benzofuran and chromene ring systems via Pd II-catalyzed oxidative cyclization
So, Won Youn,Jeong, Im Eom
, p. 3355 - 3358 (2007/10/03)
(Chemical Equation Presented) We herein report the development of one-pot procedures for the conversion of allyl aryl ethers to 2-methylbenzofurans (via sequential Claisen rearrangement and oxidative cyclization) and for the conversion of aryl homoallyl e
Intramolecular Photochemical Reactions of Bichromophoric 3-(Alkenyloxy)phenols and 1-(Alkenyloxy)-3-(alkyloxy)benzene Derivatives. Acid-Catalyzed Transformations of the Primary Cycloadducts
Hoffmann, Norbert,Pete, Jean-Pierre
, p. 6952 - 6960 (2007/10/03)
Irradiation of 3-(alkenyloxy)phenols and 1-(alkenyloxy)-3-(alkyloxy)benzene derivatives, at λ = 254 nm in acidic media, yields benzocyclobutenes, 3-alkylphenols, 3-alkylanisols, and 4-alkyl-1,2dialkyloxybenzenes depending on the substitution pattern of the aromatic ring and the olefinic side chain. The final products are derived from an intramolecular [2 + 2] photocycloaddition and acidic rearrangements from a common intermediate.
SYNTHETIC CONNECTIONS TO THE AROMATIC DIRECTED METALATION REACTION. RADICAL-INDUCED CYCLIZATION TO SUBSTITUTED BENZOFURANS, BENZOPYRANS, AND FUROPYRIDINES
Shankaran, K.,Sloan, C. P.,Snieckus, V.
, p. 6001 - 6004 (2007/10/02)
The ortho-iodoaryl allyl ethers 2, derived from 1 via the aromatic directed metalation protocol, undergo tributyl tin hydride-induced heteroring annelation to lead to unusually substituted benzofuran (3) and benzopyran, and furopyridine derivatives (Table).
