104967-74-0

Basic information

• Product Name: tert-butyl4-formylisoindoline-2-carboxylate
• Synonyms: tert-butyl4-formylisoindoline-2-carboxylate
• CAS NO: 104967-74-0
• Molecular Formula: C15H12N2
• Molecular Weight: 220.27
• Mol File: 104967-74-0.mol

Chemical Properties

• Melting Point: 175.5-177.0 °C(Solv: benzene (71-43-2))
• Boiling Point: 402.9±25.0 °C(Predicted)
• Density: 1.194±0.06 g/cm3(Predicted)
• CAS DataBase Reference: tert-butyl4-formylisoindoline-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl4-formylisoindoline-2-carboxylate(104967-74-0)
• EPA Substance Registry System: tert-butyl4-formylisoindoline-2-carboxylate(104967-74-0)

Safety Data

• Hazardous Substances Data: 104967-74-0(Hazardous Substances Data)

Upstream product

• 107916-43-8 3-(4-nitrophenyl)quinoline 
• 181420-00-8 N-[2-(3,3-Diethoxy-prop-1-ynyl)-phenyl]-acetamide 
• 540-37-4 p-aminoiodobenzene 
• 1666-96-2 3-phenylquinoline 
• 19585-90-1 3-phenyl-quinoline-2,4-dicarboxylic acid 
• 1207760-36-8 3-quinolinylzinc bromide 
• 19591-17-4 o-iodoacetanilide 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 107915-36-6 3-(p-hydroxyphenyl)-quinoline 

Relevant articles and documents

2-Pyridyl and 3-pyridylzinc bromides: direct preparation and coupling reaction

A facile synthetic approach to the direct preparation of 2-pyridyl and 3-pyridylzinc bromides has been demonstrated using Rieke zinc with 2-bromopyridine and 3-bromopyridine, respectively. A variety of different electrophiles have been coupled with the resulting organozinc reagents to give the corresponding cross-coupling products in moderate to good yields.

NOVEL HETEROCYCLIC AMIDE DERIVATIVES HAVING DIHYDROOROTATE DEHYDROGENASE INHIBITING ACTIVITY

Novel heterocyclic amide derivatives having pharmacological effects, that is, compounds represented by the general formula (1) or salts thereof: (1) wherein X1-X2 is S-CH2 or the like; R1 is alkyl or the like; p is 0 to 7; R2 is hydrogen, alkyl, or the like; R3 is hydrogen, alkyl, or the like; Y1-Y2 is CH=CH or the like; R4 is halogeno, alkyl, or the like; q is 0 to 4; and R5 is halogeno, hydrogen, alkyl, or the like.

Palladium-catalysed hydroarylation and hydrovinylation of 3,3-dialkoxy-1-aryl-1-propynes. An approach to 3-aryl- and 3-vinylquinolines

Acetylenic acetals and ketals have been reacted with aryl and vinyl halides to generate hydroarylation and hydrovinylation products. The reaction proceeds with high regioselectivity. The carbopalladation step appears to be mainly controlled by steric effects and the new carbon-carbon bond is generated preferentially on the carbon bearing the acetal group. The reaction has been employed to develop a regioselective synthesis of 3-aryl and 3-vinylquinolines.

A SIMPLE REGIOSELECTIVE PREPARATION OF 2- OR 3-SUBSTITUTED QUINOLINE DERIVATIVES VIA DIALKYLQUINOLYLBORANES

Various quinoline derivatives possessing a substituent at the 2- or 3-position were prepared by the reaction of dialkylquinolylboranes and organic bromides in the presence of a palladium catalyst.