105202-53-7Relevant academic research and scientific papers
α-Nitro-α,β-Unsaturated Ketones: An Electrophilic Acyl Transfer Reagent in Catalytic Asymmetric Friedel-Crafts and Michael Reactions
Parida, Chandrakanta,Maity, Rajendra,Chandra Sahoo, Subas,Chandra Pan, Subhas
, p. 6700 - 6704 (2019/09/07)
Herein, we introduce α-nitro-α,β-unsaturated ketones as efficient electrophilic acyl transfer reagents, and they were employed in Friedel-Crafts as well as in Michael reactions. The desired acyl transfer products of these reactions were obtained in high yields with high to excellent enantioselectivities with t-leucine-derived squaramide catalyst under mild reaction conditions. Few applications including a synthesis of the isoxazoline motif have been demonstrated.
Synthesis of Heterocyclic Compounds XLIX . An Unexpected Synthesis of Isoxazolamines
Ciller, J. A.,Seoane, C.,Soto, J. L.
, p. 1663 - 1665 (2007/10/02)
Reaction of 3-aryl-1-phenyl-2-nitropropenones 1 with potassium cyanide leads to 4-aryl-3-benzoyl-5-isoxazolamines 5 in a one-step process involving the formal reduction of the nitro group followed by nucleophilic attack at the cyano group.Treatment of the isoxazolamine with an aromatic aldehyde yields the corresponding N-arylideneisoxazolamine.
