1061490-12-7

Basic information

• Product Name: 3,3-diphenyl-N-(quinolin-8-yl)propanamide
• Synonyms: 3,3-diphenyl-N-(quinolin-8-yl)propanamide
• CAS NO: 1061490-12-7
• Molecular Weight: 352.436
• Mol File: 1061490-12-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 3,3-diphenyl-N-(quinolin-8-yl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3-diphenyl-N-(quinolin-8-yl)propanamide(1061490-12-7)
• EPA Substance Registry System: 3,3-diphenyl-N-(quinolin-8-yl)propanamide(1061490-12-7)

Safety Data

• Hazardous Substances Data: 1061490-12-7(Hazardous Substances Data)

Upstream product

• 33757-46-9 8-(N-propionylamino)quinoline 
• 591-50-4 iodobenzene 
• 1453491-96-7 3-phenyl-N-(quinolin-8-yl)propanamide-D 
• 578-66-5 8-amino quinoline 
• 501-52-0 3-Phenylpropionic acid 
• 79-03-8 propionyl chloride 
• 3240-34-4 [bis(acetoxy)iodo]benzene 
• 867347-49-7 3-phenyl-N-(quinoline-8-yl)propionamide 
• 66003-76-7 Diphenyliodonium triflate 
• 58109-40-3 diphenyliodonium hexafluorophosphate 
• 1483-73-4 diphenyliodonium bromide 
• 6293-66-9 diphenyliodonium p-toluenesulfonate 

Downstream Products

• 348607-68-1 N-(4-methoxyphenyl)-3,3-diphenylpropionamide 
• 22101-10-6 N,N-dimethyl-3,3-diphenylpropionamide 
• 59684-37-6 (R)-3,3-diphenyl-N-(1-phenylethyl)propanamide 
• 348607-73-8 N-cyclohexyl-3,3-diphenylpropanamide 
• 578-66-5 8-amino quinoline 
• 23426-03-1 3,3-diphenylpropanoic acid methyl ester 

Relevant articles and documents

Palladium-Catalyzed Base-Promoted Arylation of Unactivated C(sp3)–H Bonds by Aryl Iodides: A Practical Approach To Synthesize β-Aryl Carboxylic Acid Derivatives

A highly efficient protocol for the β-arylation of carboxylic amides by aryl iodides under PdCl2(CH3CN)2/CsOAc catalysis was developed. This method was found to tolerate a broad scope of substrates and was successfully employed in the preparation of a variety of β-aryl α-amino and γ-amino acid derivatives. The utility of this method was further illustrated in the synthesis of the psychotropic drug (±)-phenibut and β-aryl bile acid analogues.

Synthesis of β-arylated alkylamides via Pd-catalyzed one-pot installation of a directing group and C(sp3)-H arylation

The synthesis of β-arylated alkylamides via alkyl C-H bond arylation has been realized by means of direct one-pot reactions of acyl chlorides, aryl iodides and 8-aminoquinoline. Depending on the structure of the starting materials, both single and double β-arylated alkylamides could be accessed.

Direct arylation of primary and secondary sp3 C-H bonds with diarylhyperiodonium salts via Pd catalysis

Palladium-catalyzed primary and secondary sp3 C-H bond arylation is reported. The method using diarylhyperiodonium salts as arylation reagents shows good functional group tolerance and proceeds under mild reaction conditions. The KIE experiment