1069-29-0

Basic information

• Product Name: DIMETHYL CYSTINATE
• Synonyms: DIMETHYL CYSTINATE;cystine dimethyl ester;3,3'-Dithiobis(L-alanine methyl) ester;3,3'-Dithiobis[(2R)-2-aminopropionic acid methyl] ester;3,3'-Dithiodi(L-alanine methyl) ester;L-Cystine dimethyl;L-Cystine-O,O-dimethyl ester;L-Cystine, 1,1'-diMethyl ester
• CAS NO: 1069-29-0
• Molecular Formula: C₈H₁₆N₂O₄S₂
• Molecular Weight: 0
• Mol File: 1069-29-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 375.491°C at 760 mmHg
• Flash Point: 180.891°C
• Appearance: /
• Density: 1.318g/cm3
• Vapor Pressure: 7.75E-06mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: DIMETHYL CYSTINATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL CYSTINATE(1069-29-0)
• EPA Substance Registry System: DIMETHYL CYSTINATE(1069-29-0)

Safety Data

• Hazardous Substances Data: 1069-29-0(Hazardous Substances Data)

Usage

General Description

Dimethyl cystinate is a chemical compound that belongs to the family of cystine derivatives. It is formed by the condensation of two molecules of dimethylamine with one molecule of cystine. DIMETHYL CYSTINATE has been investigated for its potential as a therapeutic agent for the treatment of cystinuria, a hereditary disorder characterized by the formation of cystine stones in the kidneys, bladder, and urethra. Dimethyl cystinate has been shown to have a low toxicity profile and is able to increase the solubility of cystine in the urine, which may help prevent the formation of cystine stones. Research into the use of dimethyl cystinate as a treatment for cystinuria is ongoing, and preliminary findings suggest that it may be a promising option for managing this condition.

InChI:InChI=1/C8H16N2O4S2/c1-13-7(11)5(9)3-15-16-4-6(10)8(12)14-2/h5-6H,3-4,9-10H2,1-2H3

Upstream product

• 67-56-1 methanol 
• 56-89-3 L-cystine 
• 2485-62-3 L-Cysteine methyl ester 
• 111807-83-1 4-(3-tert-butyldimethylsilyloxyphenyl)-4-methoxyspiro<1,2-dioxetane-3,2'-adamantane> 
• 32854-09-4 L-cystine dimethyl ester dihydrochloride 
• 56-89-3 cysteine disulfide 
• 7647-01-0 hydrogenchloride 
• 629-73-2 1-Hexadecene 
• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 77826-55-2 N,N'-bis(tert-butoxy)carbonyl-L-cystine dimethyl ester 
• 10389-65-8 di-t-butoxycarbonyl-L-cystine 

Downstream Products

• 123252-19-7 C₃₆H₃₈N₈O₁₀S₄ 
• 87333-22-0 3-chloro-2-acetylamino-propionic acid methylester 
• 56-89-3 cysteine disulfide 
• 23052-19-9 di-γ-glutamyl-cystine 
• 3693-95-6 N-benzyloxycarbonyl cystine methyl ester 
• 93394-80-0 methyl (6S,9R,14R)-6-benzyl-14-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-9-(methoxycarbonyl)-2,2-dimethyl-4,7-dioxo-3-oxa-11,12-dithia-5,8-diazapentadecan-15-oate 
• 77826-55-2 N,N'-bis(tert-butoxy)carbonyl-L-cystine dimethyl ester 
• 44641-43-2 cysteine methyl ester 
• 1426207-78-4 C₃₂H₃₀N₄O₆S₂ 
• 1426207-76-2 C₃₄H₃₂N₂O₆S₂ 
• 1345983-49-4 dimethyl N-{[(3R,5R)-3-butyl-3-ethyl-7-(methyloxy)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,4-benzothiazepin-8-yl]methyl}-L-cystinate 
• 26798-52-7 N,N'-bis-glycyl-L-cystine 
• 93394-81-1 bis(phenylalanyl)cystine dimethyl ester 
• 882423-74-7 2-(allyl-benzyl-amino)-3-[2-(allyl-benzyl-amino)-2-dimethylcarbamoyl-ethyldisulfanyl]-N,N-dimethyl-propionamide 

Relevant articles and documents

Cysteine-based silver nanoparticles as dual colorimetric sensors for cations and anions

We report herein the synthesis of silver nanoparticles (Ag NPs), their characterization, and anion and cation sensing properties. Freshly prepared amide-triazole Ag NPs (3a-Ag NPs and 3b-Ag NPs) could detect fluoride and cations such as Hg2+ and Cd2+ in aqueous media with a color change from pink to brown. The cysteine-based Ag NPs 5b-Ag NPs showed a colorimetric response towards H2PO4-, whereas 6-Ag NPs showed a colorimetric response towards H2PO4- and HSO4- in aqueous media.

The trans opening of ethylene diamine tetra acetic acid bis anhydride (EDTAA) with cystine-di-OMe: One-step synthesis of bihelical systems Respectfully dedicated to Professor M.V. George on the occasion of his 85th birthday

The generation of a bihelical (figure of 8) motif has been illustrated by trans opening of EDTAA with l-cystine-di-OMe and d-penicillamine disulfide-di-OMe. In the former case the open cyclic system, arising by cis addition, was secured as a minor product.

Kinetics and thermodynamics of oxidation mediated reaction in L-cysteine and its methyl and ethyl esters in dimethyl sulfoxide-d6 by NMR spectroscopy

L-Cysteine (L-Cys), L-Cysteine methyl ester (L-CysME) or L-Cysteine ethyl ester (L-CysEE), when dissolved in dimethyl sulfoxide, undergoes an oxidation process. This process is slow enough and leads to nuclear magnetic resonance (NMR) spectral changes that could be monitored in real time. The oxidation mediated transition is modeled as a pseudo-first order kinetics and the thermodynamic parameters are estimated using the Eyring's formulation. L-Cysteine and their esters are often used as biological models due to the remarkable thiol group that can be found in different oxidation states. This oxidation mediated transition is due to the combination of thiol oxidation to a disulfide followed by solvent-induced effects may be relevant in designing cysteine-based molecular models.

Expressed Protein Ligation without Intein

Proteins with a functionalized C-terminus such as a C-terminal thioester are key to the synthesis of larger proteins via expressed protein ligation. They are usually made by recombinant fusion to intein. Although powerful, the intein fusion approach suffe