107487-41-2Relevant articles and documents
Synthesis of Substituted Furan/Pyrrole-3-carboxamides through a Tandem Nucleopalladation and Isocyanate Insertion
Rajesh, Manda,Puri, Surendra,Kant, Ruchir,Reddy, Maddi Sridhar
, p. 4332 - 4335 (2016)
Access to furanyl- and pyrrolyl-3-carboxamides from readily available 3-alkyne-1,2-diols and 1-amino-3-alkyn-2-ols using isocyanate as amido surrogate is demonstrated. The approach constitutes a successful unprecedented combination of heteropalladation an
Nonclassical Mechanism in the Cyclodehydration of Diols Catalyzed by a Bifunctional Iridium Complex
González Miera, Greco,Bermejo López, Aitor,Martínez-Castro, Elisa,Norrby, Per-Ola,Martín-Matute, Belén
, p. 2631 - 2636 (2019/02/01)
1,4- and 1,5-diols undergo cyclodehydration upon treatment with cationic N-heterocyclic carbene (NHC)–IrIII complexes to give tetrahydrofurans and tetrahydropyrans, respectively. The mechanism was investigated, and a metal-hydride-driven pathway was proposed for all substrates, except for very electron-rich ones. This contrasts with the well-established classical pathways that involve nucleophilic substitution.
A metal-free transformation of alkynes to carbonyls directed by remote OH group
Chen, Dao-Qian,Guo, Chun-Huan,Zhang, Heng-Rui,Jin, Dong-Po,Li, Xue-Song,Gao, Pin,Wu, Xin-Xing,Liu, Xue-Yuan,Liang, Yong-Min
supporting information, p. 4176 - 4180 (2016/08/02)
A remote OH group-directed metal-free transformation of alkynes to carbonyl compounds has been developed. Using only HOAc and EtOH solvent, this reaction elegantly converts alkynes into valuable ketones by remote hydroxyl group activation. Through comparison and isotope labeling experiments, it was confirmed that the process operates via a hydration reaction involving an acetic acid molecule, instead of a water molecule.
