109720-10-7

Upstream product

• 148-18-5 sodium N,N-diethyldithiocarbamate 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 292638-85-8 acrylic acid methyl ester 
• 108-88-3 toluene 
• 147-84-2 Diethyldithiocarbamic acid 
• 97-77-8 disulfiram 
• 123726-16-9 bis(4-methylphenyl)iodonium trifluoromethanesulfonate 
• 103-19-5 di(p-tolyl) disulfide 
• 5720-05-8 4-methylphenylboronic acid 
• 624-31-7 4-tolyl iodide 
• 75-15-0 carbon disulfide 
• 109-89-7 diethylamine 
• 106-49-0 p-toluidine 
• 3899-96-5 4-methylphenyl tosylate 

Downstream Products

• 21784-96-3 n-butyl 4-methylphenyl sulfide 
• 59693-93-5 (4-methylphenyl)cyclohexyl sulfane 
• 103-19-5 di(p-tolyl) disulfide 
• 5023-60-9 1-benzylsulfanyl-4-methyl-benzene 

Relevant academic research and scientific papers

Copper-mediated coupling of boronic acids, amines, and carbon disulfide: An approach to organic dithiocarbamates

An efficient copper-mediated three-component coupling reaction of boronic acids, amines, and carbon disulfide has been developed, which provides a new approach to a wide range of functionalized dithiocarbamates in good to excellent yields. The present methodology has many advantages, such as mild reaction conditions, easily available substrates, wide substrate scope, and high functional-group tolerance.

Chemoselective C–S/S–S Formation between Diaryl Disulfides and Tetraalkylthiuram Disulfides

An efficient C–S/S–S formation for the chemoselective synthesis of aryl dithiocarbamate (C–S formation) and aryl dialkylcarbamo(dithioperoxo)thioate (S–S formation) was studied. The chemoselectivity could be controlled by modulating the reaction temperature, base, and catalyst. The transformation features a simple reaction, easily available starting materials, high selectivity and easy performance, showing its practical synthetic value for the preparation of some potential biologically or pharmaceutically active compounds.

Copper-Catalyzed Synthesis of S-Aryl Dithiocarbamates from Tetraalkylthiuram Disulfides and Aryl Iodides in Water

An efficient approach for the copper-catalyzed synthesis of aryl dithiocarbamates from aryl iodides and tetraalkylthiuram disulfides in water is described. Without additional ligand and organic solvent, the coupling reaction could provide a series of S-aryl dithiocarbamates in moderate to good yields.

Copper-Catalyzed S-Arylation Starting from Arylboronic Acids and Tetraalkylthiuram Disulfide

A convenient and useful protocol for the synthesis of diverse S-aryl dithiocarbamates was studied. Starting from arylboronic acid and tetraalkylthiuram disulfide, copper-catalyzed C–S coupling proceeds smoothly to give the desired S-aryl dithiocarbamates in good to excellent yields. The broad substrate scope, short reaction time, easy performance, cheap substrates, and nice yields make this approach attractive, showing its practical synthetic value for the preparation of some biologically or pharmaceutically active compounds.

A Highly Efficient CuCl 2 -Catalyzed C-S Coupling of Aryl Iodides with Tetraalkylthiuram Disulfides: Synthesis of Aryl Dithiocarbamates

A highly efficient copper(II)-catalyzed C-S cross-coupling reaction of aryl iodides with tetraalkylthiuram disulfides was developed. With only 1 mol% of CuCl 2 as catalyst, zinc powder as reductant, and K 2 CO 3 as base, aryl iodides reacted with tetraalkylthiuram disulfides in DMSO furnishing the corresponding aryl dithiocarbamates in good to excellent yields. This protocol is an improvement of previous work, it features convenient performance, low addition of catalyst, no requirement for any ligand, and provides good yields. The method has a broad substrate scope and uses cheap and readily available starting materials.

Copper-Catalyzed C(sp2)-S Coupling Reactions for the Synthesis of Aryl Dithiocarbamates with Thiuram Disulfide Reagents

An efficient protocol for the copper-catalyzed preparation of aryl dithiocarbamates from aryl iodides and inexpensive, environmentally benign tetraalkylthiuram disulfides was developed. The features of mild reaction conditions, high yields, and broad substrate scope render this new approach synthetically attractive for the preparation of potentially biologically active compounds.

A magnetically recyclable iron oxide-supported copper oxide nanocatalyst (Fe3O4-CuO) for one-pot synthesis of: S -aryl dithiocarbamates under solvent-free conditions

A green, convenient and efficient procedure is reported for the synthesis of S-aryl dithiocarbamates by a simple one-pot three component Ullmann-type condensation of an amine, carbon disulfide and an aryl iodide. Magnetically separable and reusable copper

A method for the synthesis of thio-carbamate

The invention belongs to the technical field of chemical synthesis and discloses a dithiocarbamate synthesis method. The dithiocarbamate synthesis method comprises that in an organic solvent, Ar-B(OH)2, NHR1R2 and carbon disulfide as raw materials and a copper salt and alkali as promoters undergo a reaction at a temperature of 60-120 DEG C for 10-24h with stirring, after the reaction, the reaction product is cooled to a room temperature, then is filtered and then is subjected to reduced pressure distillation for solvent removal so that a crude product is obtained, and the crude product is purified by column chromatography so that dithiocarbamate is obtained. The dithiocarbamate synthesis method realizes dithiocarbamate synthesis by one step, has simple and easy processes and a high product yield, utilizes cheap and easily available raw materials, has a low synthesis cost and has great industrial production values.

Transition-Metal-Free C-S Bond Formation: Aqueous Synthesis of S-Aryl Dithiocarbamates by the use of Stable Arenediazonium Salts Mediated by Nano-Magnetic Supported Silica Sulfonic Acid

A convenient and transition-metal-free method for the synthesis of S-aryl dithiocarbamates based on the reaction of stable arenediazonium nano-magneto silica sulfates (ArN2+-OSO3-SiO2@Fe3O4) with dithiocarbamic acid at room temperature was studied. Avoiding the use of any hazardous transition metal, simple procedure, low cast, and short reaction time are noteworthy advantages of this methodology.