110396-65-1

Upstream product

• 1026938-03-3 (3-methyl-1-(phenylsulfonyl)-1H-indol-2-yl)methanol 
• 83-34-1 3-Methylindole 
• 98-09-9 benzenesulfonyl chloride 
• 85678-41-7 N-benzenesulphonyl-2-methyl-3-thiophenoxyindole 
• 68-12-2 N,N-dimethyl-formamide 
• 164261-56-7 1-(Phenylsulfonyl)-3-methyl-2-(bromomethyl)indole 
• 868081-89-4 1-phenylsulfonyl-3-methyl-2-chloromethylindole 
• 58550-84-8 N-(phenylsulphonyl)-3-methylindole 
• 4885-02-3 Dichloromethyl methyl ether 
• 91-55-4 2,3-dimethylindole 
• 116325-48-5 N-benzenesulfonyl-2,3-dimethyl-1H-indole 
• 868081-88-3 1-phenylsulfonyl-3-phenylthio-2-chloromethylindole 

Downstream Products

• 958238-20-5 Ethyl 3'-<1-(phenylsulfonyl)-3-(bromomethyl)indol-2-yl>acrylate 
• 1026929-37-2 Diethyl <<1-(phenylsulfonyl)-2-(β-carbethoxyvinyl)indol-3-yl>methyl>phosphonate 
• 856251-66-6 methyl (E)-3-[3-methyl-1-(phenylsulfonyl)-1H-indol-2-yl]acrylate 
• 1026938-03-3 (3-methyl-1-(phenylsulfonyl)-1H-indol-2-yl)methanol 
• 1428793-19-4 C₂₄H₂₃NO₅S 

Relevant academic research and scientific papers

Palladium(0)-Catalyzed Intermolecular Asymmetric Cascade Dearomatization Reaction of Indoles with Propargyl Carbonate

An intermolecular asymmetric cascade dearomatization reaction of indole derivatives with propargyl carbonate was developed. The challenges associated with both the chemoselectivity between the carbon and nitrogen nucleophile and the enantioselective control during the formation of an all-carbon quaternary stereogenic center were well addressed by a Pd catalytic system derived from the Feringa ligand. A series of enantioenriched multiply substituted fused indolenines were provided in good yields (71–86 %) with excellent enantioselectivity (91–96 % ee) and chemoselectivity (3/4>19:1 in most cases).

FLINDEROLE ANALOGUES AND PROCESS FOR SYNTHESIS THEREOF

The present invention discloses flinderole compounds/analogues of formula I and to a process for the preparation of same, comprising stereo- and regioselective [3+2] cycloaddition reaction of a tertiary alcohol (1a') and a sulphonated diene (1b') in presence of Lewis acid selected from Cu(OTf)2 or BF3OEt2 and a non-polar solvent at room temperature. The flinderole compounds /analogues of the instant invention and prepared by the process described therein is represented by the general formula I,(The formula I should be inserted here) wherein R1-R4 are described herein in the specification.

Biomimetic total syntheses of flinderoles B and C

A simple and efficient biomimetic synthesis of pyrrolo[1,2-a]indoles using a highly stereo- and regioselective [3 + 2] reaction cascade was developed and then further applied in the first total synthesis of flinderoles B and C, which proceeded in 17.2% yield over the longest linear sequence of 11 steps.

Synthesis of N-protected indolaldehydes using modified Hass procedure

A detailed study on oxidation of N-protected bromomethylindoles into the respective aldehydes was carried out. Using a modified Hass procedure, synthesis of aryl-/hetero-aryl aldehydes in particular indolaldehydes is achieved in reasonable yields.

A facile synthesis of 1-phenylsulfonyl-3-substituted-2-cyanoindoles, 1-phenylsulfonyl-2-methyl-3-cyanoindoles, and bifunctional 1- phenylsulfonylindoles

A facile 'one-pot' introduction of the cyano group into the 2/3-position of indole has been developed from the corresponding aldehydes using anhydrous aluminum chloride and sodium azide. Georg Thieme Verlag Stuttgart.

A facile preparation of N-protected indolaldehydes using a modified Hass procedure

The preparation of a variety of N-protected indolaldehydes is reported via the reaction of N-protected bromomethylindoles with 2-nitropropane using NaH/DMF.

A facile synthesis of 1,4-diacylbenzenes

An efficient method for the synthesis of 1,4-diacylbenzenes has been developed employing bis-tetrabutylammonium dichromate as an oxidant. By this methodology, a series of aldehydes and ketones have been synthesised under mild reaction conditions in moderate yields.

A Versatile Construction of the 8H-Quinocarbazole Ring System as a Potential DNA Binder

A short synthesis of the quino- and quinocarbazoles is repoerted.The key step of the synthesis involves the preparation of suitable 2,3-divinylindoles by consecutive Wittig reactions.The thermal electrocyclic reaction of the divinylindole wi

2-FORMYL-3-METHOXYMETHYLINDOLE, 3-ETHOXYMETHYL-2-FORMYLINDOLE AND 2-FORMYL-3-METHYLINDOLE

Base-catalysed hydrolysis of 2-formyl-3-methyl-1-phenylsulphonylindole results in the formation of 3-alkoxymethyl-2-formylindoles.Cleavage of the 1-phenylsulphonyl group with sodium amalgam produces 2-hydroxymethyl-3-methylindole.