1611-02-5

Upstream product

• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 64-17-5 ethanol 
• 29392-77-6 sodium 3-ethoxy-3-oxo-1-phenylprop-1-en-1-olate 
• 506-77-4 cyanogen chloride 
• 105-56-6 ethyl 2-cyanoacetate 
• 65-85-0 benzoic acid 
• 66129-60-0 (E)-ethyl 2-(N,N-dimethylaminomethyliden) benzoylacetate 
• 100-47-0 benzonitrile 
• 60759-50-4 3-acyl-2-oxazolone(R=Ph) 
• 50784-69-5 5-phenyl-isoxazole-4-carboxylic acid ethyl ester 
• 98-88-4 benzoyl chloride 
• 141-52-6 sodium ethanolate 
• 91-22-5 quinoline 
• 13745-35-2 (1-methyl-1H-benzo[d]imdiazol-2-yl)(phenyl)methanone 

Downstream Products

• 77916-78-0 2-methyl-3-phenylpropylamine 
• 614-16-4 Benzoylacetonitrile 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 10488-87-6 ethyl 2-benzoylpropionate 
• 500301-58-6 7-chloro-4-hydroxy-2-phenyl-quinoline-3-carboxylic acid 
• 118521-05-4 2-phenylmethylene-6-cyano-7-phenyl-5H-thiazolo<3,2-a>pyrimidine-3,5(2H)-dione 
• 124-38-9 carbon dioxide 
• 93-89-0 benzoic acid ethyl ester 
• 141-78-6 ethyl acetate 
• 113307-35-0 4-methyl-2,5-diphenyl-1,2-dihydro-pyrazol-3-one 
• 93-55-0 1-phenyl-propan-1-one 
• 28781-74-0 3-Anilino-3-aethoxy-2-cyan-acrylsaeure-aethylester 
• 1572-11-8 5-amino-3-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 110802-16-9 4-hydroxy-7-chloro-2-phenylquinoline 

Relevant academic research and scientific papers

Preparation method for alpha-cyano-beta-carbonyl propionate compound

The invention discloses a preparation method for an alpha-cyano-beta-carbonyl propionate compound. The method comprises the following steps: with organic acid and a cyanopropionate compound as raw materials and N,N-carbonyl diimidazole as an auxiliary age

COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combinatio

Synthesis and cyclization reaction of pyrazolin-5-one derivatives

A versatile synthetic method for preparing 3-pyrazolin-5-ones and 5,8-dihydro-1H-pyrazolo[1,2-a]pyridazines from simple β-keto esters is demonstrated. The synthetic strategies involve the acylation of β-keto esters, cyclocondensation with hydrazine followed by trapping with a diene under oxidative conditions.

Catalytic action of azolium salts. VIII. Oxidative aroylation with arenecarbaldehydes catalyzed by 1,3-dimethylbenzimidazolium iodide

Refluxing of a mixture of benzaldehyde (1a), 1,3- dimethylbenzimidazolium iodide (7), p-nitroaniline (9b) as an oxidizing agent, and 1,8-diazabicyclo[5,4,0]-7-undecene (DBU) in MeOH afforded methyl benzoate (2a) in good yield. Other methyl arenecarboxylates 2 were similarly obtained from arenecarbaldehydes 1. We showed that this aroylation proceeds via the 2-aroyl-1,3-dimethylbenzimidazolium salt (8). The 1,2,4-triazolium salt (18) and the naphtho[1,2-d]imidazolium salt (19) were also effective catalysts for this oxidative aroylation. However, the aroylation did not proceed with the imidazolium salt (20). In the presence of flavins (25a - c), arenecarbaldehydes 1 reacted in MeOH under aerobic conditions catalyzed by the benzimidozolium salt 7 to give the corresponding methyl arenecarboxylates 2. 1-Methyl-3-[3-(10-phenylisoalloxazin-3-yl)propyl]benzimidazolium bromide (27) is an effective complex catalyst for this oxidative aroylation.

Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles. X. Synthesis of 5-Substituted Ethyl or Methyl 4-Isoxazolecarboxylates and Methyl 4-(2,2-Dimethyl-1-oxopropyl)-5-isoxazolecarboxylate

Reaction of ethyl or methyl 2-dimethylaminomethylene-3-oxoalkanoates with hydroxylamine hydrochloride in methanol solution afforded in high yields the relative esters of 5-substituted 4-isoxazolecarboxylic acids II.These esters were hydrolyzed generally with concentrated hydrochloric acid-acetic acid mixtures to the corresponding carboxylic acids in satisfactory yields.Ethyl or methyl esters II isomerized with sodium ethoxide or methoxide, respectively, to the corresponding esters or hemiesters of 2-cyano-3-oxoalkanoic acids generally in excellent to satisfactory yields.Reaction of methyl 5,5-dimethyl-3-dimethylaminomethylene-2,4-dioxohexanoate with hydroxylamine hydrochloride afforded in moderate yield methyl 4-(2,2-dimethyl-1-oxopropyl)-5-isoxazolecarboxylate, which was converted by acid hydrolysis as above to 4-t-butyl-4-hydroxyfuroisoxazol-6-(4H)-one.

ACTIVATION OF CARBOXYL GROUPS BY DIPHENYL 2-OXO-3-OXAZOLINYLPHOSPHONATE. FACILE PREPARATION OF VERSATILE REAGENTS, 3-ACYL-2-OXAZOLONES

Synthetic utility of the 2-oxazolone moiety as an excellent new leaving group is described.Based on such a function of the heterocycles, diphenyl 2-oxo-3-oxazolinylphosphonate has been newly introduced as a carboxyl-activating reagent which permits a facile direct preparation of 3-acyl-2-oxazolones and amides including peptides from a wide variety of carboxylic acids.The 3-acyl-2-oxazolides also serve as versatile reactive agents for highly chemoselective acyl-transfer to the nucleophilic species such as amines, alcohols and thiols, providing convenient and high-yield routes to amides, esters and thiol esters under mild conditions.They are also useful intermediates for ketones and alcohols.