111108-72-6

Usage

Uses

Used in Organic Synthesis:
3-(bromomethyl)-2-chloropyridine is used as a building block in organic synthesis for the production of agrochemicals, pharmaceuticals, and fine chemicals. Its reactive functional groups allow it to undergo various chemical reactions, such as nucleophilic substitution and palladium-catalyzed cross-coupling reactions, to generate a wide range of derivatives with potential applications in the fields of medicine and industry.
Used in Pharmaceutical Industry:
3-(bromomethyl)-2-chloropyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity enable the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
3-(bromomethyl)-2-chloropyridine is used as a starting material for the synthesis of agrochemicals, such as pesticides and herbicides. Its versatility in chemical reactions allows for the creation of effective and targeted agrochemicals to protect crops and enhance agricultural productivity.
Used in Fine Chemicals Industry:
3-(bromomethyl)-2-chloropyridine is used in the production of fine chemicals, which are high-purity chemicals used in various applications, including research, diagnostics, and specialty manufacturing. Its unique properties make it a valuable component in the development of these high-quality chemicals.

InChI:InChI=1/C6H5BrClN/c7-4-5-2-1-3-9-6(5)8/h1-3H,4H2

Upstream product

• 42330-59-6 (2-chloropyrid-3-yl)methanol 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 2942-59-8 2-chloronicotinic acid 
• 18368-76-8 2 chloro-3-methylpyridine 

Downstream Products

• 1001082-95-6 [(2-chloropyridin-3-yl)methyl]triphenylphosphonium bromide 
• 7076-11-1 5,6,7,8-tetrahydro-9H-pyrido<2,3-b>indole 
• 10299-69-1 2,3-dimethyl-1H-pyrrolo[2,3-b]pyridine 

Relevant academic research and scientific papers

Iron-Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp3)–H Amination

An iron-catalyzed denitrogenative rearrangement of 1,2,3,4-tetrazole is developed over the competitive C(sp3)–H amination. This catalytic rearrangement reaction follows an unprecedented metalloradical activation mechanism. Employing the developed method, a wide number of complex-N-heterocyclic product classes have been accessed. The synthetic utility of this radical activation method is showcased with the short synthesis of a bioactive molecule. Collectively, this discovery underlines the progress of radical activation strategy that should find wide application in the perspective of medicinal chemistry, drug discovery and natural product synthesis research.

N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE

The invention relates to compounds of formula (I), or a salt thereof wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ανβ1 integrin inhibitors that are useful for treating tissue specific fibrosis.

METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS

The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.

Bridged 5,6,7,8-tetrahydro-1,6-naphthyridines, analogues of huperzine A: Synthesis, modelling studies and evaluation as inhibitors of acetylcholinesterase

Derivatives of 6,8-bridged 5,6,7,8-tetrahydro-1,6-naphthyrid-ines, designed as analogues of huperzine A, were synthe-sised and evaluated as inhibitors of acetylcholinesterase. In a first approach, C3-bridged naphthyridines were constructed by internal nucleophilic aromatic substitution of 2-chloro-3-(1-piperidinylmethyl)pyridine precursors containing a 3-CO 2Me group on the 1-piperidinyl ring moiety. Alternatively, ring-closing metathesis on 6,8-diallyl-substituted tetrahydro-1,6-naphthyridines was applied to construct an unsaturated C4 bridge. Some of the target compounds showed inhibition of acetylcholinesterase but lower than that of huperzine A. The relative order of inhibition activities could be rationalised by comparative docking simulation studies on the basis of the known crystal structure of the ace-tylcholinesterase-huperzine A complex.

Azolylmethyloxiranes, Their Use for Controlling Phytopathogenic Fungi, and Compositions Comprising Them

The present invention relates to azolylmethyloxiranes of the general formula I in which A or B is a 6-membered heteroaryl selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl and triazinyl which is substituted by one to thr

Generation and intermodular additions of pyridylmethyl radicals

2-, 3-, or 4-Pyridylmethyl radicals can be made to add to nonactivated alkenes to give a variety of otherwise inaccessible pyridine derivatives. Bicyclic structures can be obtained by combining the radical addition with ionic ring-closure steps. Georg Thieme Verlag Stuttgart.

AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R 5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.

Fused heterotricyclic compounds as inhibitors of 17beta-hydroxysteroid dehydrogenase 3

Fused heterotricyclic compounds, methods of using such compounds in the treatment of hormone sensitive diseases such as prostate cancer, and pharmaceutical compositions containing such compounds.

Heterobicyclic herbicides

Compounds of Formula I, and their N-oxides and agriculturally-suitable salts, are disclosed which are useful for controlling undesired vegetation STR1 wherein: X and Y are independently N or CH;Z is O, S(O) n, NR 7, C( O), C( S), C( N--OR 8), CH(OR 9), or