111108-72-6

Basic information

• Product Name: 3-(bromomethyl)-2-chloropyridine
• Synonyms: 3-(bromomethyl)-2-chloropyridine;Pyridine, 3-(bromomethyl)-2-chloro-
• CAS NO: 111108-72-6
• Molecular Formula: C₆H₅BrClN
• Molecular Weight: 206.4676
• Mol File: 111108-72-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 262.5°C at 760 mmHg
• Flash Point: 112.5°C
• Appearance: /
• Density: 1.663g/cm³
• Vapor Pressure: 0.0177mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: 2-8°C
• PKA: -0.21±0.10(Predicted)
• CAS DataBase Reference: 3-(bromomethyl)-2-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(bromomethyl)-2-chloropyridine(111108-72-6)
• EPA Substance Registry System: 3-(bromomethyl)-2-chloropyridine(111108-72-6)

Safety Data

• Hazardous Substances Data: 111108-72-6(Hazardous Substances Data)

Usage

General Description

3-(bromomethyl)-2-chloropyridine is a chemical compound with a molecular formula C6H5BrClN and a molecular weight of 190.48 g/mol. It is a white to light yellow crystalline solid that is characterized by its reactive bromomethyl and chloropyridine functional groups. 3-(bromomethyl)-2-chloropyridine is commonly used as a building block in organic synthesis for the production of agrochemicals, pharmaceuticals, and fine chemicals. It can undergo various chemical reactions, including nucleophilic substitution and palladium-catalyzed cross-coupling reactions, to generate a wide range of derivatives with potential applications in the fields of medicine and industry. The chemical and physical properties of 3-(bromomethyl)-2-chloropyridine make it a valuable tool for organic chemists and researchers in the development of new chemical compounds.

InChI:InChI=1/C6H5BrClN/c7-4-5-2-1-3-9-6(5)8/h1-3H,4H2

Upstream product

• 18368-76-8 2 chloro-3-methylpyridine 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 2942-59-8 2-chloronicotinic acid 
• 42330-59-6 (2-chloropyrid-3-yl)methanol 

Downstream Products

• 7076-11-1 5,6,7,8-tetrahydro-9H-pyrido<2,3-b>indole 
• 10299-69-1 2,3-dimethyl-1H-pyrrolo[2,3-b]pyridine 
• 1001082-95-6 [(2-chloropyridin-3-yl)methyl]triphenylphosphonium bromide 

Relevant articles and documents

Iron-Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp3)–H Amination

An iron-catalyzed denitrogenative rearrangement of 1,2,3,4-tetrazole is developed over the competitive C(sp3)–H amination. This catalytic rearrangement reaction follows an unprecedented metalloradical activation mechanism. Employing the developed method, a wide number of complex-N-heterocyclic product classes have been accessed. The synthetic utility of this radical activation method is showcased with the short synthesis of a bioactive molecule. Collectively, this discovery underlines the progress of radical activation strategy that should find wide application in the perspective of medicinal chemistry, drug discovery and natural product synthesis research.

METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS

The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.

Azolylmethyloxiranes, Their Use for Controlling Phytopathogenic Fungi, and Compositions Comprising Them

The present invention relates to azolylmethyloxiranes of the general formula I in which A or B is a 6-membered heteroaryl selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl and triazinyl which is substituted by one to thr