7076-11-1

Usage

Uses

Used in Pharmaceutical Research:
5,6,7,8-TETRAHYDRO-1H-PYRIDO[2,3-B]INDOLE is used as a research compound for investigating its genotoxic and carcinogenic effects, which can help in understanding its contribution to the development of cancer. This knowledge can aid in the development of potential therapeutic agents or preventive measures against cancer.
Used in Neurodegenerative Disease Research:
In the field of neurodegenerative disease research, 5,6,7,8-TETRAHYDRO-1H-PYRIDO[2,3-B]INDOLE is utilized as a subject of study to explore its role in conditions such as Parkinson's and Alzheimer's. Understanding its impact on these diseases can contribute to the advancement of treatments and interventions.
Used in Neurotransmitter Regulation Studies:
5,6,7,8-TETRAHYDRO-1H-PYRIDO[2,3-B]INDOLE is used as an inhibitor of the enzyme monoamine oxidase in studies focused on neurotransmitter regulation. This application can provide insights into the compound's effects on brain chemistry and potentially lead to the development of new approaches for managing neurological conditions related to neurotransmitter imbalances.

InChI:InChI=1/C11H12N2/c1-2-6-10-8(4-1)9-5-3-7-12-11(9)13-10/h3,5,7H,1-2,4,6H2,(H,12,13)

Upstream product

• 1135-36-0 cyclohexanone pyridin-2-ylhydrazone 
• 86119-84-8 phosphoric acid 
• 13534-99-1 2-Amino-3-bromopyridine 
• 108-94-1 cyclohexanone 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 111108-72-6 (2-chloro-3-pyridinyl)methyl bromide 
• 42330-59-6 (2-chloropyrid-3-yl)methanol 
• 2942-59-8 2-chloronicotinic acid 
• 54231-33-3 3-bromo-2-nitropyridine 
• 33948-36-6 2-iodocyclohex-2-en-1-one 
• 35486-42-1 2-amino-3,5-dibromopyridine 
• 74803-20-6 9-acetyl-5,6,7,8-tetrahydro-9H-pyrido<2,3-b>indole 
• 54230-88-5 8-bromotetrazolo[1,5-a]pyridine 
• 52200-48-3 3-bromo-2-chloropyridine 

Downstream Products

• 244-76-8 α-carboline 

Relevant academic research and scientific papers

Iron-Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp3)–H Amination

An iron-catalyzed denitrogenative rearrangement of 1,2,3,4-tetrazole is developed over the competitive C(sp3)–H amination. This catalytic rearrangement reaction follows an unprecedented metalloradical activation mechanism. Employing the developed method, a wide number of complex-N-heterocyclic product classes have been accessed. The synthetic utility of this radical activation method is showcased with the short synthesis of a bioactive molecule. Collectively, this discovery underlines the progress of radical activation strategy that should find wide application in the perspective of medicinal chemistry, drug discovery and natural product synthesis research.

TRICYCLIC CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Ir-Catalyzed Intramolecular Transannulation/C(sp2)-H Amination of 1,2,3,4-Tetrazoles by Electrocyclization

An efficient strategy for the intramolecular denitrogenative transannulation/C(sp2)-H amination of 1,2,3,4-tetrazoles bearing C8-substituted arenes, heteroarenes, and alkenes is described. The process involves the generation of the metal-nitrene intermediate from tetrazole by the combination of [CpIrCl2]2 and AgSbF6. It has been shown that the reaction proceeds via an unprecedented electrocyclization process. The method has been successfully applied for the synthesis of a diverse array of α-carbolines and 7-azaindoles.

A Unified Approach to the Isomeric α-, β-, γ-, and δ-Carbolines via their 6,7,8,9-Tetrahydro Counterparts

A cross-coupling/reductive cyclization protocol has been employed in a unified approach to all four carbolines. So, for example, the 2-nitropyridine 8, which is readily prepared through an efficient palladium-catalyzed Ullmann cross-coupling reaction, is reductively cyclized under conventional conditions to give 6,7,8,9-tetrahydro-α-carboline that is itself readily aromatized to give α-carboline (1).

Palladium-catalyzed one-pot synthesis of pyrrole-annulated coumarin, quinolone, and 7-aza-indole derivatives

An efficient one-pot approach for the synthesis of highly substituted pyrrolocoumarin, quinolone, and pyrrolopyridine derivatives has been achieved by palladium acetate catalyzed reaction in DMF through initially formed enamine from cyclic and acyclic ketones and 6-amino-5-bromocoumarin, 6-amino-5-bromo-1-methyl quinolone, and 2-amino-3,5-dibromopyridine, respectively. Georg Thieme Verlag Stuttgart - New York.

One-pot synthesis of azaindoles via palladium-catalyzed α-heteroarylation of ketone enolates

(Figure presented) A convenient, one-pot method for the construction of a variety of azaindoles using simple ketones and haloaminopyridines is described.

Ring Opening or Rearrangement versus N-Oxidation in the Action of Peracids upon Pyrrolopyridines, Pyrrolopyrazines, and Triazolo- and Triazolo-pyrazine. Some Chemical and Spectroscopic Properties of the Triazolopyrazines and Th

Peracid oxidation of the title heterocycles has shown a variety of reaction pathways. 1-Methyl-2,3-diphenyl-1H-pyrrolopyridine (8) gave a ring-opening product (13), while 3-methyl-2-phenyl-1H-pyrrolopyrazine gave N-benzoylurea.In contrast, t