1121-14-8

Usage

Uses

Used in Pharmaceutical Industry:
3-NITROISOXAZOLINE is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its reactivity allows for the creation of a wide range of drug molecules, contributing to the development of new treatments for various diseases and conditions.
Used in Agricultural Chemical Industry:
In the agricultural sector, 3-NITROISOXAZOLINE is utilized as a precursor in the production of agricultural chemicals. Its incorporation into these products helps in the development of more effective pesticides and other agrochemicals that protect crops from pests and diseases.
Used as an Antifungal Agent:
3-NITROISOXAZOLINE is studied for its potential use as an antifungal agent. It is believed to disrupt the growth and reproduction of certain fungi, making it a promising candidate for the development of new antifungal treatments and products.
Used as an Antibacterial Agent:
Similarly, 3-NITROISOXAZOLINE is also being investigated for its antibacterial properties. Its ability to inhibit the growth and reproduction of certain bacteria positions it as a potential component in the development of new antibacterial drugs and applications.

InChI:InChI=1/C3H4N2O3/c6-5(7)3-1-2-8-4-3/h1-2H2

Upstream product

• 6497-13-8 3a-nitro-tetrahydro-isoxazolo[2,3-b]isoxazol-3-ol 
• 74-85-1 ethene 
• 4122-46-7 4-hydroxy-3-nitro-2-isoxazoline N-oxide 
• 13223-78-4 tetranitroethylene 
• 109-70-6 1.3-chlorobromopropane 
• 110-46-3 isopentyl nitrite 

Downstream Products

• 65150-72-3 3-benzenesulfonyl-4,5-dihydro-isoxazole 
• 65150-71-2 3-phenylsulfanyl-4,5-dihydro-isoxazole 
• 191277-30-2 3-benzyloxy-Δ²-isoxazoline 
• 247079-77-2 3-(4-hydroxy-2-butynyl)oxy-Δ²-isoxazoline 
• 40784-13-2 3-methoxy-4,5-dihydro-isoxazole 
• 7599-99-7 3-hydroxy-2-[(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)methyl]-5,5-dimethylcyclohex-2-en-1-one 
• 129012-67-5 2-(4',5'-dihydroisoxazol-3'-yl)-5,5-dimethylcyclohexane-1,3-dione 

Relevant academic research and scientific papers

Convergent, short synthesis of the muscarinic superagonist iperoxo

Up to now the availability of iperoxo, an important superagonist of the muscarinic acetylcholine receptors, was limited because the synthesis of its precursor, the iperoxo base, was characterized by low yields, laborious chromatography and low reproducibility. Here we report a robust convergent three-step synthesis by means of a Mannich reaction and nucleophilic substitution at the 3-nitro-Δ2-isoxazoline. The new route combines short reaction time, high reproducibility and an overall yield increased from 12% to 42%.

QUINOLINONE AND BENZOXAZINE DERIVATIVES AS MUSCARINIC M1 AND/OR M4 RECEPTOR AGONISTS

This invention relates to compounds having activity as muscarinic M1 or M1 and M4 receptor agonists which are useful in the treatment of diseases mediated by the muscarinic M1 and M4 receptors. Also p

Nitroisoxazoles by manganese(IV) oxide oxidation of nitro-4,5-dihydroisoxazoles

Aryl and alkyl substituted 3- and 5-nitroisoxazole derivatives were prepared from the appropriate 3- and 5-nitro-4,5-dihydroisoxazoles using manganese(IV) oxide as oxidizing agent. Some of the 3-nitro-4-substituted isoxazoles were prepared directly by rea

Synthesis and Reaction of Tetranitroethylene

Tetranitroethylene was isolated in 50 percent yield by flash vacuum pyrolysis of heksanitroethane.Critical for the isolation is a trap temperature such that dinitrogen tetraoxide is not condensed.Tetranitroethylene reacted quantitatively with anthracene to give 11,11,12,12,-tetranitro-9,10-dihydro-9,10-ethanoanthracene, and competition experiments with anthracene showed that tetranitroethylene is at least an order of magnitude more reactive than tetracyanoethylene.Tetranitroethylene reacted with cyclopentadiene to give 5,5,6,6-tetranitronorbornene and with ethanolto give ethyl dinitroacetate.Acetylenes and olefins reacted with tetranitroethylene to give 3-nitroisoxazoles and 3-nitro-2-isoxazolines, respectively.