1126519-18-3

Upstream product

• 100-39-0 benzyl bromide 
• 591-51-5 phenyllithium 
• 103-80-0 phenylacetyl chloride 
• 646516-78-1 5-Oxo-bicyclo[4.2.0]octane-1-carboxylic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester 
• 51012-66-9 2-benzyl-2-bromoacetophenone 
• 100-58-3 phenylmagnesium bromide 
• 40145-79-7 1,2-diphenyldiazoethane 
• 100-52-7 benzaldehyde 
• 5171-96-0 (1,2-diphenylethylidene)hydrazine 
• 451-40-1 phenyl benzyl ketone 
• 2935-35-5 (S)-2-phenylglycine 

Relevant academic research and scientific papers

SYNTHESIZING METHOD OF α-TERTIARY ARYL KETONE

The present invention relates to a synthesizing method of alpha-tertiary aryl ketone. The synthesizing method of alpha-tertiary aryl ketone synthesizes alpha-tertiary aryl ketone by making aldehyde react with aryldiazoalkanes under a chiral boron Lewis ac

Rhodium-Catalyzed Enantioselective Isomerization of Secondary Allylic Alcohols

The first catalytic enantioselective isomerization of secondary allylic alcohols to access ketones with a α-tertiary stereocenter is presented. The racemic allylic alcohol substrates can be converted to the enantioenriched ketone products in a stereoconvergent fashion. The use of commercially available catalysts and mild reaction conditions makes this an attractive method in stereoselective synthesis.

Catalytic Asymmetric Formal Insertion of Aryldiazoalkanes into the C-H Bond of Aldehydes: Synthesis of Enantioenriched Acyclic α-Tertiary Aryl Ketones

A novel, catalytic enantioselective route to synthesize a variety of α-tertiary aryl ketones via a boron Lewis acid promoted formal insertion of aryldiazoalkane into the C-H bond of both aromatic and aliphatic aldehydes is described. In the presence of ch

Deaminative and decarboxylative catalytic alkylation of amino acids with ketones

It cuts two ways: The cationic [Ru-H] complex catalyzes selective coupling of α- and β-amino acids with ketones to form α-alkylated ketone products. The reaction involves C-C and C-N bond cleavage which result in regio- and stereoselective alkylation using amino acids. A broad substrate scope and high functional-group tolerance is demonstrated. Copyright

Catalytic asymmetric cross-couplings of racemic α-bromoketones with arylzinc reagents

(Chemical Equation Presented) Nickel box: The first catalytic asymmetric method for cross-coupling arylzinc reagents with α-bromoketones has been developed (see scheme). This stereoconvergent carbon-carbon bond-forming process occurs under unusually mild conditions and without activators, thereby allowing the generation of potentially labile tertiary stereocenters.

Application of A Recyclable Pseudoephedrine Resin in Asymmetric Alkylations on Solid Phase

A pseudoephedrine resin has been successfully employed in asymmetric alkylations on solid phase. Immobilized pseudoephedrine amides are conveniently prepared by the one-step attachment of pseudoephedrine to Merrifield resin through the hydroxyl group and subsequent acylation on nitrogen. Deprotonation and alkylation of the resin-bound amides proceeds smoothly. Ketones and alcohols are cleaved from the resin in high enantiomeric excess and moderate to good overall yield. The parallel, asymmetric solid-phase synthesis of a small library of chiral ketones and alcohols has been carried out to illustrate the utility of the approach. Finally, the pseudoephedrine resin can be conveniently recycled and utilized with no significant loss in the yield or enantiomeric excess of the products.

Evaluation of a Pseudoephedrine Linker for Asymmetric Alkylations on Solid Phase

(Equation Presented) Immobilized pseudoephedrine amides have been conveniently prepared by attachment of pseudoephedrine to Merrifield resin and acylation on nitrogen. Deprotonation and alkylation of the resin bound amides proceeds smoothly. Products were cleaved from the resin to give ketones and alcohols in high enantiomeric excess and moderate to good overall yield.