112891-29-9

Basic information

• Product Name: Isoquinoline, 1-(4-chlorophenyl)-3,4-dihydro-
• CAS NO: 112891-29-9
• Molecular Formula: C15H12ClN
• Molecular Weight: 241.72
• Mol File: 112891-29-9.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Isoquinoline, 1-(4-chlorophenyl)-3,4-dihydro-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoquinoline, 1-(4-chlorophenyl)-3,4-dihydro-(112891-29-9)
• EPA Substance Registry System: Isoquinoline, 1-(4-chlorophenyl)-3,4-dihydro-(112891-29-9)

Safety Data

• Hazardous Substances Data: 112891-29-9(Hazardous Substances Data)

Upstream product

• 74-11-3 para-chlorobenzoic acid 
• 623-03-0 4-Cyanochlorobenzene 
• 60-12-8 2-phenylethanol 
• 1196-38-9 3,4-dihydroisoquinolin-1(2H)-one 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 112891-30-2 1-(4-chlorophenyl)-1,2,3,4-tetrahydroisoquinoline 
• 14157-05-2 1-(methylsulfanyl)-3,4-dihydroisoquinoline 
• 1679-18-1 4-Chlorophenylboronic acid 
• 64-04-0 phenethylamine 
• 122-01-0 4-chloro-benzoyl chloride 
• 39887-24-6 N-(2-phenylethyl)-p-chlorobenzamide 

Downstream Products

• 877754-47-7 C₃₄H₂₆ClNO₂ 
• 1381986-37-3 (R)-1-(4-chlorophenyl)-2-tosyl-1,2,3,4-tetrahydroisoquinoline 
• 126115-18-2 2-benzyl-1-(4-chlorophenyl)-1-methyl-1,2,3,4-tetrahydroisoquinoline 
• 877754-54-6 C₃₄H₂₆ClN₃ 
• 855645-62-4 1-(4-chloro-phenyl)-3,4-dihydro-[7]isoquinolylamine 

Relevant articles and documents

New synthetic approach for the preparation of 1-Aryl-3,4-dihydroisoquinolines by liebeskind-srogl reaction

An efficient synthetic methodology has been developed to construct 1-aryl-3,4-dihydroisoquinoline derivatives. The reaction was performed under neutral conditions by a palladium-catalyzed desulfitative carbon-carbon cross-coupling protocol.

Diprotonative stabilization of ring-opened carbocationic intermediates: conversion of tetrahydroisoquinoline to triarylmethanes

Superacid-promoted conversion of tetrahydroisoquinolines to triarylmethanes via tandem reactions of C-N bond scission, Friedel-Crafts alkylation, C-O bond scission, and electrophilic aromatic amidation was developed. Dication formation was important for stabilizing the ring-opened carbocationic intermediate, which is a new role for diprotonation in reaction mechanisms. This journal is

A Method for Bischler-Napieralski-Type Synthesis of 3,4-Dihydroisoquinolines

A new method for the Bischler-Napieralski-type synthesis of 3,4-dihydroisoquinolines was developed by a Tf2O-promoted tandem annulation from phenylethanols and nitriles. Its success was mainly due to the fact that a phenonium ion was formed in the process and practically functioned as a stable and reactive primary phenylethyl carbocation.