114051-14-8

Basic information

• Product Name: Proline, 1-benzoyl-, methyl ester
• Synonyms: 1-Benzoyl-pyrrolidine-2-carboxylic acid methyl ester;N-benzoylproline methyl ester;1-benzoyl-2-carboxymethylpyrrolidine;1-benzoyl-2-methoxycarbonylpyrrolidine
• CAS NO: 114051-14-8
• Molecular Formula: C13H15NO3
• Molecular Weight: 233.267
• Mol File: 114051-14-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Proline, 1-benzoyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Proline, 1-benzoyl-, methyl ester(114051-14-8)
• EPA Substance Registry System: Proline, 1-benzoyl-, methyl ester(114051-14-8)

Safety Data

• Hazardous Substances Data: 114051-14-8(Hazardous Substances Data)

Upstream product

• 2133-40-6 methyl pyrrolidine-2-carboxylate hydrochloride 
• 108-88-3 toluene 
• 98-88-4 benzoyl chloride 
• 43041-12-9 methyl pyrrolidine-2-carboxylate 
• 67-56-1 methanol 
• 195719-48-3 N-benzoylproline 
• 2133-40-6 L-proline methyl ester monohydrochloride 
• 186581-53-3 diazomethane 

Downstream Products

• 128243-98-1 methyl 1-benzoyl-2-(nitrilomethyl)pyrrolidine-2-carboxylate 
• 72351-42-9 [2-(hydroxymethyl)-1-pyrrolidinyl](phenyl)methanone 
• 117918-27-1 N-benzoyl-4-bromo-2-(methoxycarbonyl)pyrrole 
• 117918-26-0 N-benzoyl-3-bromo-2-(methoxycarbonyl)pyrrole 
• 103322-12-9 methyl N-benzoylpyroglutamate 
• 86658-75-5 1-benzoyl-5-methoxy-2-methoxycarbonylpyrrolidine 

Relevant articles and documents

Copper-amino group complexes supported on silica-coated magnetite nanoparticles: Efficient catalyst for oxidative amidation of methyl arenes

Magnetite nanoparticles coated with mesoporous silica, Fe3O4@SiO2, were prepared. Surface functionalization of this core-shell nanocomposite with (3-aminopropyl)trimethoxysilane (APTMS) followed by its reaction with Cu(OAc)2 was used to develop a new heterogeneous copper complex (Fe3O4@SiO2-APTMS-Cu). The structure and composition of the synthesized nanocatalyst were characterized by FTIR, SEM, VSM, TEM, XRD, and ICP analyses. The catalytic activity of the synthesized catalyst was probed in the oxidative amidation reaction of methyl arenes with amine hydrochloride salts. Various primary, secondary, and tertiary amides were prepared by this method. The magnetic properties of this catalyst lead to easy separation as well as providing significant catalyst recyclability. The catalyst is reusable 6 times without significant decrease in its catalytic activity.

PREPARATION AND ENANTIOMERIC SEPARATION OF 7-(3-PYRIDINYL)-1,7-DIAZASPIRO[4.4] NONANE AND NOVEL SALT FORMS OF THE RACEMATE AND ENANTIOMERS

A novel scalable synthesis for the preparation of 7-(3- pyridinyI)- 1,7- diazaspiro[4.4)nonane has been developed, and7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane salts have been formed with succinic acid and oxalic acid. Additionally, 7-(3-pyridinyl)-1,7- diazaspiro[4.4]nonane has been separated into its stereoisomers via resolution with L and D di-p-toluoyltartaric acids, giving (R)- and (S)-7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane of high enantiomeric purity. Numerous solid salts of the resulting (R)- and (S)-7-(3-pyridinyl)-1,7- diazaspiro[4.4}nonane have been prepared. Methods for the preparation of the racemic and enantiomeric salts, pharmaceutical compositions comprising such salts, and uses thereof are disclosed. The salts can be administered to patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, to treat and/or prevent such disorders.

Ulicyclamide and ulithiacyclamide, two new small peptides from a marine tunicate

-