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1143-72-2

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  • 2,3,4-Trihydroxybenzophenone CAS 1143-72-2 IN Stock 2,3,4-Triphydroxy benzophenone CAS 1143-72-2

    Cas No: 1143-72-2

  • USD $ 3.5-5.0 / Kiloliter

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1143-72-2 Usage

Uses

2,3,4-Trihydroxybenzophenone is used in manufacturing method of electrophotographic photosensitive member containing styrene acrylic resin particle and melamine formaldehyde resin particle.

Definition

ChEBI: 2,3,4-trihydroxbenzophenone is a benzenetriol that is benzophenone in which one of the phenyl groups is substituted by hydroxy groups at positions 2, 3, and 4. It is a redox mediator. It has a role as a quorum sensing inhibitor, an EC 1.14.18.1 (tyrosinase) inhibitor, a human urinary metabolite, a rat metabolite and a drug metabolite. It is a hydroxybenzophenone and a benzenetriol.

Preparation

Preparation by reaction of benzoic acid with pyrogallol, in the presence of zinc chloride during 3 h at 145°;in the presence of Amberlyst-15 (a strongly acid ion exchanger) in chlorobenzene during 10 h at 131–132° (60%);in the presence of Amberlite IR-120 or Zeokarb 225 (cation exchange resins, sulfonic acid type) during 3 h at 160° (14%);in the presence of boron trifluoride in ethyl ether at 0° (44%).

General Description

2,3,4-Trihydroxybenzophenone is a hydroxylated benzophenone UV filter and has been quantitated in sea water samples by dispersive liquid-liquid microextraction followed by GC-MS. Estrogenic activity of 2,3,4-trihydroxybenzophenone has been tested by yeast-two hybrid assay.

Flammability and Explosibility

Notclassified

Check Digit Verification of cas no

The CAS Registry Mumber 1143-72-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,4 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1143-72:
(6*1)+(5*1)+(4*4)+(3*3)+(2*7)+(1*2)=52
52 % 10 = 2
So 1143-72-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H10O4/c14-10-7-6-9(12(16)13(10)17)11(15)8-4-2-1-3-5-8/h1-7,14,16-17H

1143-72-2 Well-known Company Product Price

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  • Alfa Aesar

  • (A18315)  2,3,4-Trihydroxybenzophenone, 98%   

  • 1143-72-2

  • 25g

  • 299.0CNY

  • Detail
  • Alfa Aesar

  • (A18315)  2,3,4-Trihydroxybenzophenone, 98%   

  • 1143-72-2

  • 100g

  • 832.0CNY

  • Detail
  • Alfa Aesar

  • (A18315)  2,3,4-Trihydroxybenzophenone, 98%   

  • 1143-72-2

  • 500g

  • 3105.0CNY

  • Detail

1143-72-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,3,4-Trihydroxybenzophenone

1.2 Other means of identification

Product number -
Other names Methanone, phenyl(2,3,4-trihydroxyphenyl)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1143-72-2 SDS

1143-72-2Relevant articles and documents

Synthesis method of 2,3,4-trihydroxybenzophenone

-

Paragraph 0031-, (2020/06/17)

The invention relates to a preparation method of polyhydroxy benzophenone, and concretely relates to a synthesis method of 2,3,4-trihydroxybenzophenone. The invention aims to solve the technical problems of complex operation, long reaction time and certain difficulty in an industrialization process when 2,3,4-trihydroxybenzophenone is prepared in the prior art. The synthesis method of 2,3,4-trihydroxybenzophenone comprises the following steps: adding pyrogallol and benzoic acid as raw materials into a solvent, heating to 80-140 DEG C under the action of a catalyst, separating water until no water is separated out, carrying out a heat preservation reaction, cooling to 60-100 DEG C after the reaction is finished, filtering out the catalyst, cooling to 0-60 DEG C, and filtering out the product; and continuously adding the solvent, phloroglucinol and benzoic acid into the filtered catalyst and mother liquor of the product, and repeating the reaction. The method has the following characteristics: the operation is simple, the environmental pollution is small, the requirement on equipment is low, no metal ions are introduced or used in the whole process, and the synthesized 2,3,4-trihydroxybenzophenone meets the manufacturing requirement of microelectronic circuit products.

Synthesis and biological evaluation of polyhydroxy benzophenone as mushroom tyrosinase inhibitors

Wu, Jianlong,Hu, Xuesen,Ma, Lin

experimental part, p. 449 - 452 (2012/01/04)

A series of polyhydroxy benzophenone were synthesized and evaluated as mushroom tyrosinase inhibitors. The results demonstrated that most of the target compounds had remarkable inhibitory activities on mushroom tyrosinase. Among all these compounds, 2,3,4,3′,4′,5′-hexahydroxy-diphenylketone 10 was found to be the most potent tyrosinase inhibitor with IC50 value of 1.4 μM. In addition, the inhibition kinetics analyzed by Lineweaver-Burk plots revealed that such compounds were competitive inhibitors. These results suggested that such compounds might be utilized for the development of new candidate for treatment of dermatological disorders.

Synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones: Evaluating the minimum structure for apoptosis induction by gambogic acid

Kuemmerle, Jared,Jiang, Songchun,Tseng, Ben,Kasibhatla, Shailaja,Drewe, John,Cai, Sui Xiong

, p. 4233 - 4241 (2008/09/21)

We have reported the discovery of gambogic acid (GA) as a potent apoptosis inducer and the identification of transferrin receptor as its molecular target. In order to understand the basic pharmacophore of GA for inducing apoptosis and to discover novel and simplified derivatives as potential anti-cancer agents, we explored the synthesis of caged 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones (4-oxatricyclo[4.3.1.0]decan-2-ones). Three types of 2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-ones based on xanthone, 2-phenylchromene-4-one and benzophenone, were synthesized using a Claisen/Diels-Alder reaction cascade. All the reactions produced the targeted caged compound as well as its neo-isomer. The caged compounds based on xanthone and 2-phenylchromene-4-one were found to maintain the apoptosis inducing and cell growth inhibiting activity of GA, although with less potency. The caged compounds based on benzophenone were found to be inactive. Our study determined the minimum structure of GA for its apoptosis inducing activity, which could lead to the development of simple derivatives as potential anti-cancer drugs.

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