1145-92-2

Basic information

• Product Name: phenyl(2-phenylcyclopropyl)methanone
• CAS NO: 1145-92-2
• Molecular Formula: C₁₆H₁₄O
• Molecular Weight: 222.2818
• Mol File: 1145-92-2.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 357.4°C at 760 mmHg
• Flash Point: 155.1°C
• Density: 1.143g/cm³
• Vapor Pressure: 2.73E-05mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: phenyl(2-phenylcyclopropyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(2-phenylcyclopropyl)methanone(1145-92-2)
• EPA Substance Registry System: phenyl(2-phenylcyclopropyl)methanone(1145-92-2)

Safety Data

• Hazardous Substances Data: 1145-92-2(Hazardous Substances Data)

Upstream product

• 93-58-3 benzoic acid methyl ester 
• 3234-51-3 1,1-dibromo-2-phenylcyclopropane 
• 591-51-5 phenyllithium 
• 16619-19-5 N-morpholinocinnamide 
• 75-09-2 dichloromethane 
• 94-41-7 benzalacetophenone 
• 75-11-6 diiodomethane 
• 20662-53-7 4-(2-keto-1-benzimidazolinyl)piperidine 
• 42509-29-5 4-chloro-1,3-diphenyl-1-butanone 
• 39512-49-7 4-(4-chlorophenyl)-4-hydroxypiperidine 
• 4660-02-0 (+/-)-trans-2-phenylcyclopropanecarbonitrile 
• 1774-47-6 trimethylsulfoxonium iodide 
• 614-47-1 1,3-diphenyl-propen-3-one 
• 100-52-7 benzaldehyde 

Downstream Products

• 14533-17-6 (1Z,3E)-1-chloro-1,4-diphenylbuta-1,3-diene 

Relevant articles and documents

Synthesis, structure, and reactivity of iminosulfonium ylides bearing an α-carbonyl group

Treatment of methyl(methylimino)diphenylsulfonium tetraphenylborate (3) with NaH and subsequent acylation produced a new type of iminosulfonium ylides bearing an α-carbonyl group 5. The molecular structure of iminosulfonium phenacylide 5a was determined by X-ray crystallographic analysis. The ylide 5 reacted further with methyl triflate affording the corresponding novel alkylidenesulfonium salts 6.

"Instant methylide" modification of the Corey-Chaykovsky cyclopropanation reaction

Treatment of various electron-deficient alkenes in DMSO with stable, dry, equimolar mixtures of either Me3S(O)I/KOt-Bu or Me 3S(O)I/NaH cleanly afforded the corresponding substituted cyclopropanes in good yields and short reaction ti

Facile synthesis of libraries of functionalized cyclopropanes and oxiranes using ionic liquids – A new approach to the classical Corey-Chaykovsky reaction

The potential of [PAIM][NTf2]/BMIM-ILs as a base/solvent in the Corey-Chaykovsky reaction is demonstrated by the facile synthesis of libraries of functionalized cyclopropanes from enones and oxiranes from aldehydes and ketones, at room temperature in respectable isolated yields. To demonstrate their application, the synthesized epoxides were employed as substrates for the synthesis of a library of 2,3-disubstituted quinolines, using [BMIM(SO3H)][OTf]/[BMIM][PF6] as a catalyst/solvent. The potential for recycling/reuse of the IL solvents was also explored.

Bromomethyl Silicate: A Robust Methylene Transfer Reagent for Radical-Polar Crossover Cyclopropanation of Alkenes

A general protocol for visible-light-induced cyclopropanation of alkenes was developed with bromomethyl silicate as a methylene transfer reagent, offering a robust tool for accessing highly valuable cyclopropanes. In addition to α-aryl or methyl-substituted Michael acceptors and styrene derivatives, the unactivated 1,1-dialkyl ethylenes were also shown to be viable substrates. Apart from realizing the cyclopropanation of terminal alkenes, the methyl transfer reaction has been further demonstrated to be amenable to the internal olefins. The photocatalytic cyclopropanation of 1,3-bis(1-arylethenyl)benzenes was also achieved, giving polycyclopropane derivatives in excellent yields. With late-stage cyclopropanation as the key strategy, the synthetic utility of this transformation was also demonstrated by the total synthesis of LG100268.