128764-56-7

Basic information

• Product Name: 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole
• Synonyms: 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole
• CAS NO: 128764-56-7
• Molecular Weight: 686.251
• Mol File: 128764-56-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole(128764-56-7)
• EPA Substance Registry System: 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole(128764-56-7)

Safety Data

• Hazardous Substances Data: 128764-56-7(Hazardous Substances Data)

Upstream product

• 21615-34-9 2-Methoxybenzoyl chloride 
• 579-75-9 2-Methoxybenzoic acid 
• 114772-71-3 2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloro-5-(chloromethyl)imidazole hydrochloride 
• 114772-72-4 5-(azidomethyl)-2-butyl-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole 
• 114772-43-9 2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-methoxycarbonyl-1,1'-biphenyl-4-yl)methyl]-1H-imidazole 
• 114772-73-5 5-Aminomethyl-2-n-butyl-1-[(2'-carbomethoxybiphenyl-4-yl)methyl]-4-chloroimidazole 
• 84392-32-5 4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole 
• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 74201-13-1 N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide 
• 114772-34-8 methyl 4'-methylbiphenyl-2-carboxylate 
• 7148-03-0 o-tolylbenzoic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 624-31-7 4-tolyl iodide 
• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 

Downstream Products

• 128764-54-5 5-<<4-<<3-(N-isopropylamino)-2-hydroxypropyl>oxy>indole-2-carboxamido>methyl>-2-butyl-1-<(2'-carboxybiphenyl-4-yl)methyl>-4-chloroimidazole 

Relevant articles and documents

Nonpeptide Angiotensin II Receptor Antagonists: The Discovery of a Series of N-(Biphenylylmethyl)imidazoles as Potent, Orally Active Antihypertensives

A new series of nonpeptide angiotensin II (AII) receptor antagonists has been prepared.These N-(biphenylylmethyl)imidazoles, e.g. 2-butyl-1--4-chloro-5-(hydroxymethyl)imidazole, differ from the previously reported N-(benzamidobenzyl)imidazoles and related compounds in that they produce a potent antihypertensive effect upon oral administration; the earlier series generally were active only when administered intravenously.It has been found that the acidic group at the 2'-position of the biphenyl is essential.Only ortho-substituted acids possess both high affinity for the AII receptor and good oral antihypertensive potency.The carboxylic acid group has been replaced with a variety of acidic isosteres, and the tetrazole ring has been found to be the most effective.The tetrazole derivative, DuP 753, is currently in development for the treatment of hypertension.