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114853-62-2

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114853-62-2 Usage

General Description

(S)-1-(4-chlorophenyl)propan-1-amine hydrochloride, also known as Pseudoephedrine, is a pharmaceutical compound that acts as a decongestant and bronchodilator. It is commonly used to treat nasal and sinus congestion caused by allergies, colds, or sinus infections. Pseudoephedrine works by constricting blood vessels in the nasal passages, reducing swelling and congestion. It is available over the counter in many countries, but due to its potential use in the illegal production of methamphetamine, it is regulated in some areas and may require a prescription for purchase. Pseudoephedrine can also have stimulating effects on the central nervous system and is sometimes used as an ingredient in combination with other drugs to treat symptoms of the common cold.

Check Digit Verification of cas no

The CAS Registry Mumber 114853-62-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,8,5 and 3 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 114853-62:
(8*1)+(7*1)+(6*4)+(5*8)+(4*5)+(3*3)+(2*6)+(1*2)=122
122 % 10 = 2
So 114853-62-2 is a valid CAS Registry Number.

114853-62-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-1-(4-Chlorophenyl)propan-1-amine hydrochloride

1.2 Other means of identification

Product number -
Other names (1S)-1-(4-Chlorophenyl)-1-propanamine hydrochloride (1:1)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114853-62-2 SDS

114853-62-2Relevant articles and documents

Pharmacological studies of 1-(p-chlorophenyl)propanol and 2-(1-hydroxy-3-butenyl)phenol: Two new non-narcotic analgesics designed by molecular connectivity

Garcia-March,Garcia-Domenech,Galvez,Anton-Fos,De Julian-Ortiz,Giner-Pons,Recio-Iglesias

, p. 10 - 15 (1997)

Molecular topology has been applied to the design of new analgesic drugs. Linear discriminant analysis and connectivity functions were used to design two potentially suitable drugs which were synthesized and tested for analgesic properties by the acetic acid-induced abdominal constriction test in mice and the tail-flick test in rats. In mice, the compound 1-(p-chlorophenyl)propanol showed higher analgesic activity, both intraperitoneally and orally, than acetylsalicylic acid. 2-(1-Hydroxy-3-butenyl)phenol exhibited a lesser protective effect (70% of that shown by acetylsalicylic acid). In rats, acetylsalicylic acid gave the greatest protection against pain when administered intraperitoneally, while 1-(p-chlorophenyl)propanol was the most active orally. The 2-(1-hydroxy-3-butenyl)phenol, both intraperitoneally and orally, showed the least protective effect. These results demonstrated the peripheral analgesic properties of the selected compounds, thus confirming the validity of the molecular design method.

The Synthesis of Primary Amines through Reductive Amination Employing an Iron Catalyst

B?umler, Christoph,Bauer, Christof,Kempe, Rhett

, p. 3110 - 3114 (2020/06/01)

The reductive amination of ketones and aldehydes by ammonia is a highly attractive method for the synthesis of primary amines. The use of catalysts, especially reusable catalysts, based on earth-abundant metals is similarly appealing. Here, the iron-catalyzed synthesis of primary amines through reductive amination was realized. A broad scope and a very good tolerance of functional groups were observed. Ketones, including purely aliphatic ones, aryl–alkyl, dialkyl, and heterocyclic, as well as aldehydes could be converted smoothly into their corresponding primary amines. In addition, the amination of pharmaceuticals, bioactive compounds, and natural products was demonstrated. Many functional groups, such as hydroxy, methoxy, dioxol, sulfonyl, and boronate ester substituents, were tolerated. The catalyst is easy to handle, selective, and reusable and ammonia dissolved in water could be employed as the nitrogen source. The key is the use of a specific Fe complex for the catalyst synthesis and an N-doped SiC material as catalyst support.

PROCESS FOR THE PREPARATION OF CHIRAL AMINES FROM PROCHIRAL KETONES

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Page/Page column 5; 6, (2015/12/11)

There is provided a method for the preparation of an enantiomerically enriched amine from a prochiral ketone.

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