117574-74-0Relevant academic research and scientific papers
Dual-Mode HDAC Prodrug for Covalent Modification and Subsequent Inhibitor Release
Daniel, Kevin B.,Sullivan, Eric D.,Chen, Yao,Chan, Joshua C.,Jennings, Patricia A.,Fierke, Carol A.,Cohen, Seth M.
, p. 4812 - 4821 (2015)
Histone deacetylase inhibitors (HDACi) target abnormal epigenetic states associated with a variety of pathologies, including cancer. Here, the development of a prodrug of the canonical broad-spectrum HDACi suberoylanilide hydroxamic acid (SAHA) is describ
Radical reactions leading to substituted coumarins
Giraud, Anne,Vanelle, Patrice,Giraud, Luc
, p. 4321 - 4322 (2007/10/03)
The reaction of 4-hydroxycoumarins with a series of quinonic chlorides under photostimulation was shown to provide an efficient approach to 3- alkylated coumarin derivatives. Alkylation reactions of this type proceeded via an electron transfer mechanism (
Diels-alder trapping of ortho-quinone methides. A new entry to substituted xanthene- 1,4-diones
Giraud, Luc,Giraud, Anne
, p. 1153 - 1160 (2007/10/03)
Highly regioselective Diels-Alder reactions of a non-protected β-hydroxy quinone have been achieved after formation of chelated lithium alkoxides. In this report, we demonstrate on a model system, that the selectivity of reactions based on 1,3-dioxy-subst
Electroorganic Synthesis, 58. Synthesis of Substituted Benzoquinones and their Use for Mediated Electrochemical Conversions
Riering, Helmut,Schaefer, Hans J.
, p. 859 - 874 (2007/10/02)
Hydroxy- (1a-3a) and hydroxyalkyl-substituted benzoquinones (6a-8a, 27a), suited to be immobilized by esterification with polyacrylic acid, are prepared.Their cathodic reduction potential Ep,c (1) correlates linearly with their substituent constant.The cathodic reduction of dioxygen and the palladium(II)-catalyzed anodic oxidation of alkenes are mediated by the benzoquinones 7b, 8b and 27b, respectively. - Key Words: Benzoquinones, substituted / Cyclic voltammetry / Cathodic dioxygen reduction, mediated / Anodic Wacker oxidation, mediated
SYNTHESIS OF DIQUINONE DERIVATIVES OF DEUTEROPORPHYRIN IX FOR THE STUDY OF THE FIRST STAGE IN THE PROCESS OF PHOTOSYNTHESIS
Borovkov, V. V.,Evstigneeva, R. P.,Makova, S. Z.
, p. 142 - 147 (2007/10/02)
Diquinone derivatives of deuteroporphyrin IX containing covalent bridges of different lengths between the chromophores have been synthesized.The compounds were prepared by the condensation of hydroxy-quinones with deuteroporphyrin IX using a mixed anhydri
Quinone derivatives, their production and use.
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, (2008/06/13)
Quinone derivatives represented by the general formula (wherein, R1 and R2, which are the same or different, refer to a hydrogen atom, methyl or methoxymethyl group, or R1 and R2 bind together to form-CH=CH-CH=CH-; R3 is a hydrogen atom or methyl group; R? is a nitrogen-containing heterocyclic group which may be substituted; R? is a hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or a carboxyl group which may be (wherein, R' is a hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that, when m is 2 or 3, Z and k are able to vary appropri-ately in the repeating unit shown in [ ] ), and the hydro-quinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of poly unsaturated fatty acids, particularly two or more of inhibition of production of fatty acid peroxides, inhibition of production of metabo-lites in 5-lipoxygenase pathway, inhibition of thromboxane A? synthetase, thromboxane A? receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therapeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc.
S(RN)1 reactions of a tetrasubstituted-1,4-benzoquinone
Crozet,Giraud,Sabuco,Vanelle,Barreau
, p. 4125 - 4128 (2007/10/02)
The C-alkylation reaction of 2-chloromethyl-3,5,6-trimethyl-1,4-benzoquinone by 2-nitropropane anion is shown to proceed by the S(RN)1 mechanism. This mechanism is confirmed by the inhibitory effects of dioxygen, p-dinitrobenzene, cupric chloride and di-t
Certain benzoquinones, naphthoquinones, corresponding hydroquinones which exhibit thromboxane A2 synthetase inhibition or receptor antagonism and the like
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, (2008/06/13)
Quinone derivatives represented by the general formula STR1 (wherein, R1 and R2, the same or different, refer to a hydrogen atom, methyl or methoxymethyl group, or R1 and R2 bind together to form --CH=CH--CH=CH--; R3 is a hydrogen atom or methyl group; R4 is a nitrogen-containing heterocyclic group which may be substituted; R5 is a hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or a carboxyl group which may be esterified or amidated; Z is STR2 (wherein, R' is hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that, when m is 2 or 3, Z and k are able to vary appropriately in the repeating unit shown in [ ]), and the hydroquinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of polyunsaturated fatty acids, particularly two or more of inhibition of production of fatty acid peroxides, inhibition of production of metabolites in 5-lipoxygenase pathway, inhibition of thromboxane A2 synthetase, thromboxane A2 receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therapeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc.
