1176316-99-6

Basic information

• Product Name: AgoMelatine (hydrochloride)
• Synonyms: AgoMelatine (hydrochloride)
• CAS NO: 1176316-99-6
• Molecular Formula: C15H18ClNO2
• Molecular Weight: 279.76192
• Mol File: 1176316-99-6.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: AgoMelatine (hydrochloride)(CAS DataBase Reference)
• NIST Chemistry Reference: AgoMelatine (hydrochloride)(1176316-99-6)
• EPA Substance Registry System: AgoMelatine (hydrochloride)(1176316-99-6)

Safety Data

• Hazardous Substances Data: 1176316-99-6(Hazardous Substances Data)

Upstream product

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• 127-09-3 sodium acetate 
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• 108-24-7 acetic anhydride 
• 138112-76-2 agomelatine 

Relevant articles and documents

Melatonin compounds and preparation method and applications thereof

The invention relates to melatonin compounds and clinical applications thereof. The structure of the melatonin compounds is represented by the formula (I). The invention also provides hydrates, solvates, eutectic, and pharmaceutically acceptable salts of the melatonin compounds represented by the formula (I), and a preparation method thereof. The invention also provides a medical application of the melatonin compounds, in particular, treatment on depression or periventricular leukomalacia.

CRYSTAL FORM VII OF AGOMELATINE, PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

The present invention provides a new crystalline form VII of agomelatine, its method of preparation, application and pharmaceutical composition. This new crystalline form offers high purity, a stable crystalline structure and good reproducibility, while its method of production lends itself well to large scale production. In terms of stability and purity, it is superior to the numerous crystalline forms which have hitherto been reported. As a result, the crystalline form VII of the present invention possesses advantages in pharmaceutical preparation.

AGOMELATINE HYDROCHLORIDE HYDRATE AND PREPARATION THEREOF

The present invention relates to an agomelatine hydrochloride hydrate of formula I, preparation and use thereof, and to pharmaceutical composition containing it. The agomelatine hydrohalide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps. wherein X is Cl.