118249-07-3 Usage
General Description
1-(2-(3-iodo-4-aminophenyl)ethyl)-4-(3-(trifluoromethyl)phenyl)piperazine is a chemical compound consisting of a piperazine ring with a combination of aminophenyl, ethyl, iodine, trifluoromethyl, and phenyl groups attached. This chemical has potential pharmaceutical applications as it is structurally related to selective serotonin reuptake inhibitors (SSRIs) and serotonin receptor antagonists. The presence of iodine and trifluoromethyl groups in the compound makes it useful in radiolabeling studies, while the piperazine group confers potential for use as a central nervous system (CNS) drug. However, further studies and research are needed to fully understand the properties and potential applications of this chemical compound.
Check Digit Verification of cas no
The CAS Registry Mumber 118249-07-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,2,4 and 9 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 118249-07:
(8*1)+(7*1)+(6*8)+(5*2)+(4*4)+(3*9)+(2*0)+(1*7)=123
123 % 10 = 3
So 118249-07-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H21F3IN3/c20-19(21,22)15-2-1-3-16(13-15)26-10-8-25(9-11-26)7-6-14-4-5-18(24)17(23)12-14/h1-5,12-13H,6-11,24H2
118249-07-3Relevant articles and documents
Preparation and biodistribution of -[125I]Iodo-4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine and -[125I]Iodo-4-azidophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine
Chumpradit,Kung,Billings,Guo,Wu,Shih
, p. 543 - 547 (2007/10/02)
The iodinated analogue of 1-[2-(4-aminophenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]piperazine (PAPP), IPAPP (4), and the corresponding azido compound azido-IPAPP (5) were synthesized. The corresponding no-carrier-added 125I (T( 1/2 ) = 60 days, 35-60 keV) labeled compounds were also prepared. High specific binding was observed from in vitro binding studies using rat brain tissue preparation; K(i) = 20 and 17.5 nM against [3H]-5-HT. In vivo biodistribution studies in rats showed that azido-[125I]IPAPP passed through intact blood-brain barrier and localized in the brain. Ex vivo autoradiography of rat brain sections exhibited a diffuse uptake pattern, which may be due to specific and nonspecific binding. The results indicate that IPAPP and azido-IPAPP may not be suitable to image the serotonin receptor in the brain.
